Breast Cancer Res Treat (2018) 168:35–41 https://doi.org/10.1007/s10549-017-4563-3 CLINICAL TRIAL Characteristics and outcomes of breast cancer patients enrolled in the National Cancer Institute Cancer Therapy Evaluation Program sponsored phase I clinical trials 1 1,2 3 3 Filipa Lynce · Matthew J. Blackburn · Ling Cai · Heping Wang · 4 5 6 1 Larry Rubinstein · Pamela Harris · Claudine Isaacs · Paula R. Pohlmann Received: 24 October 2017 / Accepted: 1 November 2017 / Published online: 8 November 2017 © Springer Science+Business Media, LLC 2017 Abstract CTEP-sponsored phase I clinical trial was 614 days for all Purpose Breast cancer (BC) is the most commonly diag- patients. Breast cancer patients were enrolled on average nosed cancer and the second leading cause of cancer-related 790 days after initial diagnosis, while non-BC patients had death among women. Given the availability of approved a median enrollment time of 582 days (p < 0.001). Breast therapies and abundance of phase II and III clinical trials, cancer patients had more clinical responses than non-BC historically few BC patients have been referred for consid- patients (18.3% vs. 4.3%, respectively). Along with the eration of participation on a phase I trial. We were inter- higher rate of response, BC patients remained on phase I ested in determining whether clinical benefit rates differed trials longer than
Breast Cancer Research and Treatment – Springer Journals
Published: Nov 8, 2017
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