Channels Formed by Amphotericin B Covalent Dimers Exhibit Rectification

Channels Formed by Amphotericin B Covalent Dimers Exhibit Rectification Amphotericin B (AmB) is a widely used antifungal antibiotic with high specificity for fungi. We previously synthesized several covalently conjugated AmB dimers to clarify the AmB channel structure. Among these dimers, that with an aminoalkyl linker was found to exhibit potent hemolytic activity. We continue this work by investigating the channel activity of the dimer, finding that all channels comprised of AmB dimers show rectification. The direction of the dimer channel in the membrane depended on the electric potential at which the dimer channel was formed. On the other hand, only about half the monomer channels showed rectification. In addition, these channels were easily switched from a rectified to a nonrectified state following voltage stimulation, indicating instability. We propose a model to describe the AmB channel structure that explains why AmB dimer channels necessarily show rectification. The Journal of Membrane Biology Springer Journals

Channels Formed by Amphotericin B Covalent Dimers Exhibit Rectification

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Copyright © 2011 by Springer Science+Business Media, LLC
Life Sciences; Human Physiology ; Biochemistry, general
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