Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments

Changes in expression of the genes for chemokines, cytokines, and their receptors in response to... A study of the immunomodulating effect of selank showed that both the total peptide and its fragment significantly change the expression of the genes for chemokines, cytokines, and their receptors in mouse spleen 6 and 24 h after single administration. Changes in the mRNA level of the majority of the genes under study were observed after the administration of Gly-Pro, which was earlier identified as a selank pharmacophore, a minimum fragment with anitiviral activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795411050103
Publisher site
See Article on Publisher Site

Abstract

A study of the immunomodulating effect of selank showed that both the total peptide and its fragment significantly change the expression of the genes for chemokines, cytokines, and their receptors in mouse spleen 6 and 24 h after single administration. Changes in the mRNA level of the majority of the genes under study were observed after the administration of Gly-Pro, which was earlier identified as a selank pharmacophore, a minimum fragment with anitiviral activity.

Journal

Russian Journal of GeneticsSpringer Journals

Published: May 15, 2011

References

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