Changes in arterial pressure hemodynamics in response to renal nerve stimulation both before and after renal denervation

Changes in arterial pressure hemodynamics in response to renal nerve stimulation both before and... Background Renal nerve denervation (RDN) is developed as a potential treatment for hypertension. Recently, we reported the use of renal nerve stimulation (RNS) to localize sympathetic nerve tissue for subsequent selective RDN. The effects of RNS on arterial pressure dynamics remain unknown. The current study aimed to describe the acute changes in arterial pres- sure dynamics response to RNS before and after RDN. Methods and results Twenty six patients with drug-resistant hypertension referred for RDN were included. RNS was per- formed under general anesthesia before and after RDN. We continuously monitored heart rate (HR) and invasive femoral blood pressure (BP). Augmentation pressure (AP) and index (Aix), pulse pressure (PP), time to reflected wave, maximum systolic BP and dicrotic notch were calculated. Systolic and diastolic BP at site of maximum response significantly increased in response to RNS (120 ± 16/62 ± 9 to 150 ± 22/75 ± 15 mmHg) (p < 0.001/< 0.001), whereas after RDN no RNS-induced BP change was observed (p > 0.10). RNS increased Aix (29 ± 11 to 32 ± 13%, p = 0.005), PP (59 ± 14 to 75 ± 17  mmHg, p < 0.001), time to reflected wave (63 ± 18 to 71 ± 25 ms, p http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Kardiologie Springer Journals

Changes in arterial pressure hemodynamics in response to renal nerve stimulation both before and after renal denervation

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Cardiology
ISSN
0300-5860
eISSN
1861-0692
D.O.I.
10.1007/s00392-018-1287-2
Publisher site
See Article on Publisher Site

Abstract

Background Renal nerve denervation (RDN) is developed as a potential treatment for hypertension. Recently, we reported the use of renal nerve stimulation (RNS) to localize sympathetic nerve tissue for subsequent selective RDN. The effects of RNS on arterial pressure dynamics remain unknown. The current study aimed to describe the acute changes in arterial pres- sure dynamics response to RNS before and after RDN. Methods and results Twenty six patients with drug-resistant hypertension referred for RDN were included. RNS was per- formed under general anesthesia before and after RDN. We continuously monitored heart rate (HR) and invasive femoral blood pressure (BP). Augmentation pressure (AP) and index (Aix), pulse pressure (PP), time to reflected wave, maximum systolic BP and dicrotic notch were calculated. Systolic and diastolic BP at site of maximum response significantly increased in response to RNS (120 ± 16/62 ± 9 to 150 ± 22/75 ± 15 mmHg) (p < 0.001/< 0.001), whereas after RDN no RNS-induced BP change was observed (p > 0.10). RNS increased Aix (29 ± 11 to 32 ± 13%, p = 0.005), PP (59 ± 14 to 75 ± 17  mmHg, p < 0.001), time to reflected wave (63 ± 18 to 71 ± 25 ms, p

Journal

Zeitschrift für KardiologieSpringer Journals

Published: May 29, 2018

References

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