Neurol Sci (2017) 38:1529–1531 DOI 10.1007/s10072-017-2965-y LETTER TO THE EDITOR Cerebral large-vessel vasculitis as an unusual manifestation of POEMS syndrome 1 1 1 2 Stefano Forlivesi & Ruggero Bacchin & Manuel Cappellari & Elisa Dall’Ora & 2 1,2 Roberto Currò Dossi & Bruno Bonetti Received: 16 February 2017 /Accepted: 12 April 2017 /Published online: 21 April 2017 Springer-Verlag Italia 2017 Dear editor, A 44-year-old Caucasian man presented with peripheral POEMS syndrome (acronym for polyneuropathy, edema, ascites, and diffuse lymphadenopathy. His medical organomegaly, endocrinopathy, monoclonal gammopathy, history was noteworthy for a monoclonal gammopathy of un- and skin changes) is a rare multisystem disease associated determined significance (MGUS) diagnosed 1 year earlier. He with plasma cell dyscrasia . The pathogenesis of the syn- had no history of smoking, alcohol consumption, or recrea- drome is not well understood. A correlation has been de- tional drug use. Physical examination showed skin changes scribed between the levels of proinflammatory and (hyperpigmentation, vitiligo, and cutaneous sclerosis) and proangiogenic cytokines, such as vascular endothelial growth hepatosplenomegaly, which was confirmed by abdominal factor (VEGF), and disease activity . VEGF targets endo- computed tomography (CT) scan. Neurological examination thelial cells, induces a rapid and reversible increase in vascular
Neurological Sciences – Springer Journals
Published: Apr 21, 2017
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