Cellular-level near-wall unsteadiness of high-hematocrit erythrocyte flow using confocal μPIV

Cellular-level near-wall unsteadiness of high-hematocrit erythrocyte flow using confocal μPIV In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention. Unsteadiness is reported and quantified for the first time in the literature using a combination of fluorescent dye labeling, time-resolved scanning confocal microscopy, and micro-particle image velocimetry (μPIV). The near-wall red blood cell (RBC) motion of physiologic high-hematocrit blood in a rectangular microchannel was investigated under pressure-driven flow. Intermittent flow was associated with (1) the stretching of RBCs as they passed through RBC clusters with twisting motions; (2) external flow through local obstacles; and (3) transitionary rouleaux formations. Velocity profiles are presented for these cases. Unsteady flow clustered in local regions. Extra-cellular fluid flow generated by individual RBCs was examined using submicron fluorescent microspheres. The capabilities of confocal μPIV post-processing were verified using synthetic raw PIV data for validation. Cellular interactions and oscillating velocity profiles are presented, and 3D data are made available for computational model validation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experiments in Fluids Springer Journals

Cellular-level near-wall unsteadiness of high-hematocrit erythrocyte flow using confocal μPIV

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Copyright © 2010 by Springer-Verlag
Engineering; Engineering Thermodynamics, Heat and Mass Transfer; Engineering Fluid Dynamics; Fluid- and Aerodynamics
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