M4mmafian Brief Data Reports IncorporatIng Mouse Genome Mammalian Genome 9, 411-414 (1998). © Springer-Verlag New York Inc. 1998 20g13 . In humans, this region is known to harbor amplifica- Cellular apoptosis susceptibility gene Capts tions that correlate with aggressive breast cancer. In fact, CAPTS maps to mouse Chromosome 2 has been described as part of aberrant human chromosome 20q in several breast and colon cancer cell lines . CAPTS mRNA is Maria de Miguel,* John M. Centanni, highly expressed in tissues that contain actively dividing cells, such as human testis and fetal liver, and is elevated in lymphoid Ganesan Gopalan, Debra J. Gilbert, Neal G. Copeland, tissues, as well as in several tumor cell lines . In culture, CAPTS Nancy A. Jenkins, Peter J. Donovan expression correlates with the proliferative activity of human fi- Mammalian Genetics Laboratory, ABL-Basic Research Program, broblasts , indicating an important role in cell division. CAPTS NCI-FCRDC, PO BOX B, Bldg 539, Frederick, Maryland 21702-1201, reduction in MCF-7 breast cancer cells confers resistance to the USA Pseudomonas diphtheria apoptotic effects of toxin, toxin, and tu- mor necrosis factors alpha and beta . Human CAPTS has been Received: 20 September 1997 / Accepted: 30 December 1997
Mammalian Genome – Springer Journals
Published: Mar 27, 2009
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