J. Membrane Biol. 162, 95–100 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review S. Waldegger, F. Lang Physiologisches Institut I, Universita ¨t Tu ¨ bingen, Gmelinstr. 5, D-72076 Tu ¨ bingen, Germany Received: 10 July 1997 Introduction expression changes in response to cell volume alter- ations. The multitude of physiological and pathophysiological mechanisms challenging cell volume constancy faces a Regulation of Cell Volume Constancy Is Challenged comparable diversity of genes which are transcription- under Anisotonic and Isotonic Conditions ally modified by cell swelling or cell shrinkage. The In mammalian tissues, most cells are exposed to extra- products of some of those genes serve cell volume regu- cellular fluid with well controlled osmolarity. A notable lation e.g., by cellular accumulation of osmolytes. Other exception is the kidney medulla, where extracellular os- genes encode for transcription factors and other signaling molarity may range from isotonicity to more than 1500 molecules, presumably linking cell volume to altered ex- mOsm (Roy, Layton & Jamison, 1992) during water de- pression or function of proteins. A third group of genes privation. But even at constant extracellular osmolarity, protects proteins against the destabilizing effects of high cell volume is subjected
The Journal of Membrane Biology – Springer Journals
Published: Mar 15, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera