Cell Volume and Gene Expression

Cell Volume and Gene Expression J. Membrane Biol. 162, 95–100 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review S. Waldegger, F. Lang Physiologisches Institut I, Universita ¨t Tu ¨ bingen, Gmelinstr. 5, D-72076 Tu ¨ bingen, Germany Received: 10 July 1997 Introduction expression changes in response to cell volume alter- ations. The multitude of physiological and pathophysiological mechanisms challenging cell volume constancy faces a Regulation of Cell Volume Constancy Is Challenged comparable diversity of genes which are transcription- under Anisotonic and Isotonic Conditions ally modified by cell swelling or cell shrinkage. The In mammalian tissues, most cells are exposed to extra- products of some of those genes serve cell volume regu- cellular fluid with well controlled osmolarity. A notable lation e.g., by cellular accumulation of osmolytes. Other exception is the kidney medulla, where extracellular os- genes encode for transcription factors and other signaling molarity may range from isotonicity to more than 1500 molecules, presumably linking cell volume to altered ex- mOsm (Roy, Layton & Jamison, 1992) during water de- pression or function of proteins. A third group of genes privation. But even at constant extracellular osmolarity, protects proteins against the destabilizing effects of high cell volume is subjected http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Cell Volume and Gene Expression

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Copyright © Inc. by 1998 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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