Cell Volume and Gene Expression

Cell Volume and Gene Expression J. Membrane Biol. 162, 95–100 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review S. Waldegger, F. Lang Physiologisches Institut I, Universita ¨t Tu ¨ bingen, Gmelinstr. 5, D-72076 Tu ¨ bingen, Germany Received: 10 July 1997 Introduction expression changes in response to cell volume alter- ations. The multitude of physiological and pathophysiological mechanisms challenging cell volume constancy faces a Regulation of Cell Volume Constancy Is Challenged comparable diversity of genes which are transcription- under Anisotonic and Isotonic Conditions ally modified by cell swelling or cell shrinkage. The In mammalian tissues, most cells are exposed to extra- products of some of those genes serve cell volume regu- cellular fluid with well controlled osmolarity. A notable lation e.g., by cellular accumulation of osmolytes. Other exception is the kidney medulla, where extracellular os- genes encode for transcription factors and other signaling molarity may range from isotonicity to more than 1500 molecules, presumably linking cell volume to altered ex- mOsm (Roy, Layton & Jamison, 1992) during water de- pression or function of proteins. A third group of genes privation. But even at constant extracellular osmolarity, protects proteins against the destabilizing effects of high cell volume is subjected http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Cell Volume and Gene Expression

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Publisher
Springer Journals
Copyright
Copyright © Inc. by 1998 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900346
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 162, 95–100 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review S. Waldegger, F. Lang Physiologisches Institut I, Universita ¨t Tu ¨ bingen, Gmelinstr. 5, D-72076 Tu ¨ bingen, Germany Received: 10 July 1997 Introduction expression changes in response to cell volume alter- ations. The multitude of physiological and pathophysiological mechanisms challenging cell volume constancy faces a Regulation of Cell Volume Constancy Is Challenged comparable diversity of genes which are transcription- under Anisotonic and Isotonic Conditions ally modified by cell swelling or cell shrinkage. The In mammalian tissues, most cells are exposed to extra- products of some of those genes serve cell volume regu- cellular fluid with well controlled osmolarity. A notable lation e.g., by cellular accumulation of osmolytes. Other exception is the kidney medulla, where extracellular os- genes encode for transcription factors and other signaling molarity may range from isotonicity to more than 1500 molecules, presumably linking cell volume to altered ex- mOsm (Roy, Layton & Jamison, 1992) during water de- pression or function of proteins. A third group of genes privation. But even at constant extracellular osmolarity, protects proteins against the destabilizing effects of high cell volume is subjected

Journal

The Journal of Membrane BiologySpringer Journals

Published: Mar 15, 1998

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