Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication

Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus... In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1826-0
Publisher site
See Article on Publisher Site

Abstract

In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.

Journal

Archives of VirologySpringer Journals

Published: Feb 1, 2014

References

  • Viral manipulation of DNA repair and cell cycle checkpoints
    Chaurushiya, MS; Weitzman, MD
  • Viruses and the cell cycle
    Op De Beeck, A; Caillet-Fauquet, P
  • The anaphase-promoting complex: new subunits and regulators
    Page, AM; Hieter, P
  • Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products
    Swanton, C; Jones, N

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