Mammalian Genome 11, 696–699 (2000). DOI: 10.1007/s003350010116 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Cell- and stage-specific expression of Mage genes during mouse spermatogenesis 1, 2 2 2 1 Fre ´de ´ric Clotman, * Olivier De Backer, Etienne De Plaen, Thierry Boon, Jacques Picard Unit of Developmental Genetics, 73 avenue Mounier, B-1200 Brussels, Belgium Ludwig Institute for Cancer Research, Brussels branch, 74 avenue Hippocrate, B-1200 Brussels, Belgium Received: 4 January 2000 / Accepted: 14 March 2000 The human MAGE-A1 and MAGE-A3 genes direct the expression 1950). Thus, mouse testis provided us the opportunity to assess of antigens recognized on melanoma cell lines by autologous cy- whether Mage genes display possible stage-specific expression tolytic T lymphocytes (van der Bruggen et al. 1994a, 1994b). They during spermatogenesis. As a first step to identify possible belong to a family of related genes located in regions q28 (MAGE- Mage gene function(s) in the testis, we compared the mRNA ex- A genes; De Plaen et al. 1994), p21.3 (MAGE-B genes; Muscatelli pression of Mage-a and Mage-b genes on healthy adult mouse et al. 1995), and q26 (MAGE-C1 gene; Lucas et al. 1998) of the X testis sections. Chromosome (Chr). Several MAGE genes
Mammalian Genome – Springer Journals
Published: Feb 7, 2014
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