Mammalian Genome 10, 761–763 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 cDNA cloning and the 5*genomic organization of Naip2, a candidate gene for murine Legionella resistance 1,2 3 3 1,2 Zahra Yaraghi, Eduardo Diez, Philippe Gros, Alex MacKenzie Children’s Hospital of Eastern Ontario Research Institute, Solange Gauthier Karsh Laboratory, Ottawa, Ontario K1H 8L1, Canada Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada Received: 20 January 1999 / Accepted: 15 March 1999 NAIP (Neuronal Apoptosis Inhibitory Protein), cloned as a candi- Naip1–6-containing region of Chr 13 and the Lgn1 critical interval date gene for SMA (Spinal Muscular Atrophy; Morrison 1996), points to Naip as a candidate gene for Legionella resistance. Sup- exists in multiple copies in the SMA region of Chr 5 (5q13; Roy porting this role for Naip is the recent report suggesting that cell et al. 1995). Deletions in the first two coding exons of the func- cytotoxicity by Legionella pneumophila occurs at least in part tional copy of NAIP are associated with approximately 66% of the through apoptosis (Muller et al. 1996). We postulate that A/J mac- type
Mammalian Genome – Springer Journals
Published: Jul 1, 1999
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