cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T

cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T Short Communications Mammalian Genome 8, 346-348 (1997). 9 Springer-Verlag New York Inc. 1997 cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T Anne Koch, 1 Todd S.-C. Juan, 1 Nancy A. Jenkins, 2 Debra J. GUbert, 2 Neal G. Copeland, 2 Ian K. McNiece, 1 Frederick A. Fletcher* ~Department of Developmental Hematology, Amgen, Incorporated, MIS99-1-A, 1840 De Havilland Drive Thousand Oaks, California 91320-1789, USA 2Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA Received: 7 December 1996 / Accepted 3 January 1997 Calcium-dependent contraction of vertebrate striated muscle is rat are so highly conserved, and since the 5' and 3' ends of cDNAs regulated in part through the interaction of the troponin protein from the two species coincided, we suggest that a full-length splice complex with tropomyosin and the actin-myosin myofibril. The variant of mouse fast troponin T was cloned. Northern analysis of troponin complex consists of three proteins, troponin I (TnI), tro- adult mouse poly(A) + mRNA revealed that the fast troponin T ponin C (TnC), and troponin T (TnT). TnI is an actin-binding protein that enables the troponin complex to physically inhibit the 1 gcctgc~gctggtcctgtccacaaggagcccccagcctttctcagac~caactacaga~a interaction of Mammalian Genome Springer Journals

cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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