Mammalian Genome 9, 162-164 (1998). Mammalian Genome Incorgoraling Mouxe Gm—, © Springer-Verlag New York Inc. 1998 cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases Brian Paul Chadwick,' Jill Williamson, 2 Denise Sheer, 2 Anna-Maria Frischauf' 'Molecular Analysis of Mammalian Mutation, Imperial Cancer Research Fund, London, WC2A 3PX, UK 2Human Cytogenetics, Imperial Cancer Research Fund, London, WC2A 3PX, UK Received: 26 June 1992 / Accepted: 10 October 1997 alignment of ACRs I—IV. The high level of conservation of the Nucleoside-triphosphatases (NTPases) are divalent cation-depen- dent transmembrane glycoproteins that hydrolyze extracellular ACRs would indicate that these regions are essential for the func- nucleoside tri-and/or diphosphates (for review see Plesner 1995). tioning of the protein, while changes in the regions surrounding Several functional roles of NTPases have been proposed, in- these domains can be tolerated. It may be evolutionary changes in cluding the termination of purinergic signaling, cellular adhesion, the flanking residues that are responsible for the variation in sub- vesicular transport, purine recycling, and regulation of ecto- strate and kinetics of the different proteins. The presence of all four kinases by control of substrate concentration (Plesner 1995; Stro- ACRs in the mNTPase protein suggests that mNTPase
Mammalian Genome – Springer Journals
Published: Mar 28, 2009
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