Mammalian Genome 9, 1059–1061 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 cDNA characterization and high resolution mapping of the human SOX20 gene 1 1 2 1,2 M. Vujic ´, T. Rajic ´, P.N. Goodfellow, * Milena Stevanovic ´ Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, PO Box 794, 11001 Belgrade, Yugoslavia Department of Genetics, Cambridge University, Downing Street, Cambridge CB2 3EH, UK Received: 28 May 1998 / Accepted: 14 August 1998 SOX genes comprise a family of genes that are related to the investigated human SOX genes expressed in developing brain. To mammalian sex-determining gene, SRY. The homology is re- identify additional human SOX genes expressed in CNS during stricted to the HMG-box domain responsible for sequence-specific development, we have screened human fetal cDNA library with DNA-binding activity. Since the cloning of SRY, the identification the 250-bp fragment containing the SOX-box of human SOXA of SOX genes has proceeded rapidly, and a large number of se- gene (Stevanovic et al. 1993, 1994). A cDNA library was con- quences have been identified in a wide variety of phylogenetically structed with mRNA derived from the brains of 14 to 16 week-old diverse organisms and deposited
Mammalian Genome – Springer Journals
Published: Dec 1, 1998
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