Purpose The invasive tumor front (ITF) and pattern of invasion (POI) are significant prognosticators in head and neck cancer squamous cell carcinoma (HNSCC); this study evaluates the expression of CSC marker, CD44 at the ITF and their combined prognostic potential. Methods POI, as scored by the invasive pattern grading score (IPGS), was correlated with CD44 expression in HNSCC cell line-derived xenografts. Immunohistochemical expression of CD44 was correlated with the ITF features in patients and their combined prognostic ability assessed by multivariate analysis, Kaplan–Meier plots, and Cox regression models. Results Assessment of cell line-derived in vivo models indicated that drug-resistant, CD44-enriched cell lines led to genera- tion of xenografts with aggressive POIs (IV) at the ITF. In patients (N = 173), a near significant association of CD44 with IPGS (p = 0.05) was observed. CD44 (p = 0.02), along with differentiation ( p = 0.04), and lymphoplasmocytic infiltration (LPI) (p = 0.03) were independent prognosticators of recurrence. Notably, IPGS and poorly differentiated tumors were high low predictors of recurrence in CD44 cohort (p < 0.05), while severe LPI was a good prognosticator only in CD44 cohort (p < 0.006). In the treatment naïve cohort, the prognostic efficacy was confined to the
Oral Cancer – Springer Journals
Published: Apr 16, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera