Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture

Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory... J Mol Med (2017) 95:995–1003 DOI 10.1007/s00109-017-1555-z ORIGINAL ARTICLE Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture 1 2 2 Patricia Severino & Suely Kubo Ariga & Hermes Vieira Barbeiro & 2 1 2 Thais Martins de Lima & Elisangela de Paula Silva & Denise Frediani Barbeiro & 2 3,4 2,5 Marcel Cerqueira César Machado & Victor Nizet & Fabiano Pinheiro da Silva Received: 6 January 2017 /Revised: 15 May 2017 /Accepted: 31 May 2017 /Published online: 16 June 2017 Springer-Verlag GmbH Germany 2017 Abstract cathelicidins can exert both pro- and anti-inflammatory Antimicrobial peptides possess a myriad of molecular proper- activities depending on the disease and cellular context. ties including bacterial killing and the regulation of many aspects of innate immunity. Cathelicidins are a group of anti- Key messages & The role of cathelicidin in a CLP model is investigated microbial peptides widely investigated by the scientific com- munity. Many studies have focused on the bactericidal and using cathelicidin-KO mice. & Cathelicidin-KO mice show an enhanced immune re- pro-inflammatory roles of cathelicidins. Because the role of endogenous cathelicidin expression remains obscure in deep- sponse and improved survival rates. & An http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Medicine Springer Journals

Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture

Loading next page...
 
/lp/springer_journal/cathelicidin-deficient-mice-exhibit-increased-survival-and-qpo3KBbpfq
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Molecular Medicine; Human Genetics; Internal Medicine
ISSN
0946-2716
eISSN
1432-1440
D.O.I.
10.1007/s00109-017-1555-z
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial