J Mol Med (2017) 95:995–1003 DOI 10.1007/s00109-017-1555-z ORIGINAL ARTICLE Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture 1 2 2 Patricia Severino & Suely Kubo Ariga & Hermes Vieira Barbeiro & 2 1 2 Thais Martins de Lima & Elisangela de Paula Silva & Denise Frediani Barbeiro & 2 3,4 2,5 Marcel Cerqueira César Machado & Victor Nizet & Fabiano Pinheiro da Silva Received: 6 January 2017 /Revised: 15 May 2017 /Accepted: 31 May 2017 /Published online: 16 June 2017 Springer-Verlag GmbH Germany 2017 Abstract cathelicidins can exert both pro- and anti-inflammatory Antimicrobial peptides possess a myriad of molecular proper- activities depending on the disease and cellular context. ties including bacterial killing and the regulation of many aspects of innate immunity. Cathelicidins are a group of anti- Key messages & The role of cathelicidin in a CLP model is investigated microbial peptides widely investigated by the scientific com- munity. Many studies have focused on the bactericidal and using cathelicidin-KO mice. & Cathelicidin-KO mice show an enhanced immune re- pro-inflammatory roles of cathelicidins. Because the role of endogenous cathelicidin expression remains obscure in deep- sponse and improved survival rates. & An
Journal of Molecular Medicine – Springer Journals
Published: Jun 16, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera