J Mol Med (2017) 95:995–1003 DOI 10.1007/s00109-017-1555-z ORIGINAL ARTICLE Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture 1 2 2 Patricia Severino & Suely Kubo Ariga & Hermes Vieira Barbeiro & 2 1 2 Thais Martins de Lima & Elisangela de Paula Silva & Denise Frediani Barbeiro & 2 3,4 2,5 Marcel Cerqueira César Machado & Victor Nizet & Fabiano Pinheiro da Silva Received: 6 January 2017 /Revised: 15 May 2017 /Accepted: 31 May 2017 /Published online: 16 June 2017 Springer-Verlag GmbH Germany 2017 Abstract cathelicidins can exert both pro- and anti-inflammatory Antimicrobial peptides possess a myriad of molecular proper- activities depending on the disease and cellular context. ties including bacterial killing and the regulation of many aspects of innate immunity. Cathelicidins are a group of anti- Key messages & The role of cathelicidin in a CLP model is investigated microbial peptides widely investigated by the scientific com- munity. Many studies have focused on the bactericidal and using cathelicidin-KO mice. & Cathelicidin-KO mice show an enhanced immune re- pro-inflammatory roles of cathelicidins. Because the role of endogenous cathelicidin expression remains obscure in deep- sponse and improved survival rates. & An
Journal of Molecular Medicine – Springer Journals
Published: Jun 16, 2017
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