Int J Colorectal Dis (2017) 32:1243–1251 DOI 10.1007/s00384-017-2846-0 ORIGINAL ARTICLE γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer 1 2,3 1 1,4 Jutta Maria Nagel & Harald Lahm & Andrea Ofner & Burkhard Göke & 1,5 Frank Thomas Kolligs Accepted: 20 June 2017 /Published online: 6 July 2017 Springer-Verlag GmbH Germany 2017 Abstract effects of these molecular manipulations on the malignant Purpose γ-Catenin is a protein closely related to β-catenin. potential of the cell lines were tested in vitro and in vivo in a While the overexpression of β-catenin has been linked with xenograft tumor model. impaired prognosis and survival in various malignancies, both Results γ-Catenin contributed to Wnt signaling independent oncogenic and tumor suppressor functions have been de- of the cellular context. Unlike its sister molecule β-catenin, γ- scribed for γ-catenin. Thus, its role in cancer remains contro- catenin inhibited cellular invasion and anoikis in cells endog- versial. In this study, we examined the impact of γ-catenin enously expressing γ-catenin. In line with this tumor suppres- expression on the malignant potential of colorectal cancer sor function, its de novo expression in RKO cells inhibited cells. proliferation via cell cycle arrest. In a xenograft tumor
International Journal of Colorectal Disease – Springer Journals
Published: Jul 6, 2017
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