Purpose Adverse drug events (ADE) are among the leading types of risk factors for ADE. The broad and in-depth cover- causes of morbidity and hospitalization. This review analyzes age of risk factors and their association patterns elucidate the risk factors for ADE, particularly their categorizations and complexity of risk factor analysis. Managing risk factors for association patterns, the prevalence, severity, and preventabil- ADE is crucial for improving patient safety, particularly for ity of ADE, and method characteristics of reviewed studies. the elderly, comorbid, and polypharmacy patients. Some Methods Literature search was conducted via PubMed, under-explored risk factors such as genetics, mental health Science Direct, CINAHL, and MEDLINE. A review was con- and wellness, education, lifestyle, and physical environment ducted of research articles that reported original data about invite future research. specific risk factors for ADE since 2000. Data analyses were . . performed using Excel and R. Keywords Adverse drug events Risk factor Results We summarized 211 risk factors for ADE, and . Categorization Association analysis grouped them into five main categories: patient-, disease-, medication-, health service-, and genetics-related. Among them, medication- and disease-related risk factors were most Introduction frequently studied. We further classified risk factors within each main
European Journal of Clinical Pharmacology – Springer Journals
Published: Dec 8, 2017
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