Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light

Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or... Mussel-inspired polymers have emerged as attractive candidates for the synthesis of injectable hydrogels with tissue-adhesive properties. In these systems, polymer crosslinking occurs via the oxidative coupling of catechol groups grafted on the polymer backbone, performed in the presence of an enzyme or a chemical oxidant. Here, we show that catechol-modified hyaluronic acid (HA-CA) can self-crosslink in physiological conditions without any requirement of oxidizing reagents. A careful rheological analysis of gelation of HA-CA solutions indicated that both the degree of substitution and the molar mass of HA-CA are key parameters controlling the gelation kinetics. Interestingly, the gelation time could be dramatically lowered by photo-oxidation of catechol using visible light in the presence of eosin Y as a photosensitizer. This strategy can be advantageously used to manage viscosity and gelation kinetics during injection, which paves the way for various biomedical applications of HA-CA including wound closure and healing as well as drug delivery. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Polymer Bulletin Springer Journals

Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light

Loading next page...
 
/lp/springer_journal/catechol-modified-hyaluronic-acid-in-situ-forming-hydrogels-by-auto-Vc2ga05HZk
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Organic Chemistry
ISSN
0170-0839
eISSN
1436-2449
D.O.I.
10.1007/s00289-017-1937-y
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial