tissues compared to skeletal, periodontal, and dermal tissues. Introduction—Bone morphogenetic protein 1 (BMP1) is part of an extracellular metalloproteinase family that biosynthet- ically processes procollagen molecules. BMP1-and tolloid- Keywords—Collagen, Arterial stiffness, Pressure–volume like (TLL1) proteinases mediate the cleavage of carboxyl loop, Mammalian tolloid, Elastic modulus. peptides from procollagen molecules, which is a crucial step in ﬁbrillar collagen synthesis. Ablating the genes that encode BMP1-related proteinases (Bmp1 and Tll1) post-natally results in brittle bones, periodontal defects, and thin skin in KO conditional knockout (BT ) mice. Despite the importance INTRODUCTION of collagen to cardiovascular tissues and the adverse effects of Bmp1 and Tll1 ablation in other tissues, the impact of Members of a small family of structurally-similar Bmp1 and Tll1 ablation on cardiovascular performance is extracellular metalloproteinases, including bone mor- unknown. Here, we investigated the role of Bmp1- and Tll1- phogenetic protein 1 (BMP1), mammalian tolloid ablation in cardiovascular tissues by examining ventricular KO (mTLD), and tolloid-like 1 and 2 (TLL1, TLL2), are and vascular structure and function in BT mice. Methods—Ventricular and vascular structure and function broadly expressed in tissues and have roles in pro- KO were comprehensively quantiﬁed in BT mice (n = 9) and cessing procollagen molecules
Cellular and Molecular Bioengineering – Springer Journals
Published: Jun 5, 2018
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