Cardiovascular Disease, the Nitric Oxide Pathway and Risk of Cognitive Impairment and Dementia

Cardiovascular Disease, the Nitric Oxide Pathway and Risk of Cognitive Impairment and Dementia Purpose of Review In this review, we summarise the evidence health worldwide. The NO pathway may be a promising bio- on the association between cardiovascular disease (CVD) and logical candidate for future studies focused on reducing not cognitive impairment and explore the role of the nitric oxide only CVD but also risk of cognitive decline and dementia. (NO) pathway as a causal mechanism. . . Recent Findings Evidence from epidemiological studies sug- Keywords Cardiovascular disease Cognitive impairment . . gests that the presence of CVD and its risk factors in midlife is Dementia Endothelial function Nitric oxide associated with an increased risk of later life cognitive impair- ment and dementia. It is unclear what is driving this associa- tion but risk may be conveyed via an increase in neurodegen- Introduction eration (e.g. amyloid deposition), vascular changes (e.g. small vessel disease) and mechanistically due to increased levels of Midlife cardiovascular disease (CVD) and vascular risk fac- oxidative stress and inflammation as well as changes in NO tors have been consistently associated with an increased risk bioavailability. of later life cognitive impairment and dementia [1–3]. The underlying mechanisms explaining how CVDs and their risk factors negatively affect cognitive function are complex, Current Cardiology Reports Springer Journals

Cardiovascular Disease, the Nitric Oxide Pathway and Risk of Cognitive Impairment and Dementia

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Springer US
Copyright © 2017 by The Author(s)
Medicine & Public Health; Cardiology
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