Purpose of Review In this review, we summarise the evidence health worldwide. The NO pathway may be a promising bio- on the association between cardiovascular disease (CVD) and logical candidate for future studies focused on reducing not cognitive impairment and explore the role of the nitric oxide only CVD but also risk of cognitive decline and dementia. (NO) pathway as a causal mechanism. . . Recent Findings Evidence from epidemiological studies sug- Keywords Cardiovascular disease Cognitive impairment . . gests that the presence of CVD and its risk factors in midlife is Dementia Endothelial function Nitric oxide associated with an increased risk of later life cognitive impair- ment and dementia. It is unclear what is driving this associa- tion but risk may be conveyed via an increase in neurodegen- Introduction eration (e.g. amyloid deposition), vascular changes (e.g. small vessel disease) and mechanistically due to increased levels of Midlife cardiovascular disease (CVD) and vascular risk fac- oxidative stress and inflammation as well as changes in NO tors have been consistently associated with an increased risk bioavailability. of later life cognitive impairment and dementia [1–3]. The underlying mechanisms explaining how CVDs and their risk factors negatively affect cognitive function are complex,
Current Cardiology Reports – Springer Journals
Published: Aug 11, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera