Cardiorespiratory fitness and adiposity in breast cancer survivors:
is meeting current physical activity recommendations really enough?
Lidia B. Alejo
Received: 28 August 2017 / Accepted: 15 January 2018 / Published online: 5 February 2018
Springer-Verlag GmbH Germany, part of Springer Nature 2018
Purpose Breast cancer (BC) survivors are becoming increasingly predisposed to cardiovascular disease (CVD) mortality. Low
cardiorespiratory fitness and physical activity (PA) levels, as well as high values of adiposity indices, contribute to CVD risk. We
evaluated adiposity, cardiorespiratory profile, and PA levels in two independent cohorts of BC survivors.
Methods Data were collected from two groups (99% women) from different areas of Madrid (Spain): group 1, n = 110, age 51.4
± 9.7 years, median time from diagnosis 365 days (95% confidence interval [CI], 354–401), and group 2, n =93, age54.7±
8.9 years, 1714 days (95% CI, 1502–1938). We estimated peak oxygen uptake (VO
) and measured body mass index (BMI),
waist circumference (WC), waist-to-hip index, and accelerometry-determined PA.
Results Both groups had values of BMI in the overweight range (25.3 ± 4.3 and 27.1 ± 5.1 kg/m
, p = 0.003). Estimated VO
levels were lower in group 2 than in group 1 (28.1 ± 9.1 and 23.7 ± 8.8 ml/kg/min, p < 0.001), although levels in both groups were
low.Yet,themajorityofparticipantsinbothgroups(81and88%,p = 0.234) met international PA recommendations (235 ± 196
and 351 ± 173 min/week of moderate–vigorous PA, p < 0.001). Both groups had very low levels of vigorous PA. These results
were essentially independent of type of treatment (anthracycline/radiotherapy).
Conclusions We found a poor cardiorespiratory profile in two independent BC cohorts that differed in median time from
diagnosis (as well in socioeconomic status), supporting the notion that implementation of PA (possibly focusing on vigorous
PA) and dietary intervention is urgently needed in this patient population.
Keywords Moderate–vigorous physical activity
Alejandro Santos-Lozano, Javier Ramos and Alejandro Alvarez-Bustos
contributed equally to this work.
Luisa Soares-Miranda, Alejandro Lucia, and Ana Ruiz-Casado share se-
Electronic supplementary material The online version of this article
(https://doi.org/10.1007/s00520-018-4055-y) contains supplementary
material, which is available to authorized users.
* Luisa Soares-Miranda
Research Institute of Hospital 12 de Octubre (Bi+12^), Madrid, Spain
i+HeALTH, European University Miguel de Cervantes,
Val lad ol id, S p ain
Department of Medical Oncology, Hospital Universitario Puerta de
Hierro, Madrid, Spain
Universidad Europea de Madrid, Madrid, Spain
Department of Oncology, Hospital Universitario de Fuenlabrada,
Research Center in Physical Activity Health and Leisure, Faculty of
Sport, University of Porto, Rua Dr. Plácido Costa 91,
4200-450 Porto, Portugal
Supportive Care in Cancer (2018) 26:2293–2301