Cardiomyokines from the heart

Cardiomyokines from the heart The heart is regarded as an endocrine organ as well as a pump for circulation, since atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were discovered in cardiomyocytes to be secreted as hormones. Both ANP and BNP bind to their receptors expressed on remote organs, such as kidneys and blood vessels; therefore, the heart controls the circulation by pumping blood and by secreting endocrine peptides. Cardiomyocytes secrete other peptides besides natriuretic peptides. Although most of such cardiomyocyte-derived peptides act on the heart in autocrine/paracrine fashions, several peptides target remote organs. In this review, to overview current knowledge of endocrine properties of the heart, we focus on cardiomyocyte-derived peptides (cardiomyokines) that act on the remote organs as well as the heart. Cardiomyokines act on remote organs to regulate cardiovascular homeostasis, systemic metabolism, and inflammation. Therefore, through its endocrine function, the heart can maintain physiological conditions and prevent organ damage under pathological conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular and Molecular Life Sciences Springer Journals

Cardiomyokines from the heart

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Life Sciences; Cell Biology; Biomedicine, general; Life Sciences, general; Biochemistry, general
ISSN
1420-682X
eISSN
1420-9071
D.O.I.
10.1007/s00018-017-2723-6
Publisher site
See Article on Publisher Site

Abstract

The heart is regarded as an endocrine organ as well as a pump for circulation, since atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were discovered in cardiomyocytes to be secreted as hormones. Both ANP and BNP bind to their receptors expressed on remote organs, such as kidneys and blood vessels; therefore, the heart controls the circulation by pumping blood and by secreting endocrine peptides. Cardiomyocytes secrete other peptides besides natriuretic peptides. Although most of such cardiomyocyte-derived peptides act on the heart in autocrine/paracrine fashions, several peptides target remote organs. In this review, to overview current knowledge of endocrine properties of the heart, we focus on cardiomyocyte-derived peptides (cardiomyokines) that act on the remote organs as well as the heart. Cardiomyokines act on remote organs to regulate cardiovascular homeostasis, systemic metabolism, and inflammation. Therefore, through its endocrine function, the heart can maintain physiological conditions and prevent organ damage under pathological conditions.

Journal

Cellular and Molecular Life Sciences – Springer Journals

Published: Dec 13, 2017

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  • Selective upregulation of cardiac endothelin system in patients with ischemic but not idiopathic dilated cardiomyopathy: endothelin-1 system in the human failing heart
    Serneri, GG; Cecioni, I; Vanni, S; Paniccia, R; Bandinelli, B; Vetere, A; Janming, X; Bertolozzi, I; Boddi, M; Lisi, GF; Sani, G; Modesti, PA
  • Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy
    Shohet, RV; Kisanuki, YY; Zhao, XS; Siddiquee, Z; Franco, F; Yanagisawa, M
  • Endogenous endothelin-1 is required for cardiomyocyte survival in vivo
    Zhao, XS; Pan, W; Bekeredjian, R; Shohet, RV
  • Role of endothelin in uteroplacental circulation and fetal vascular function
    Paradis, A; Zhang, L
  • The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties
    Helle, KB; Corti, A; Metz-Boutigue, MH; Tota, B
  • The release of protein from the stimulated adrenal medulla
    Banks, P; Helle, K
  • Secretion of a chromaffin granule protein, chromogranin, from the adrenal gland after splanchnic stimulation
    Blaschko, H; Comline, RS; Schneider, FH; Silver, M; Smith, AD
  • Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function
    Pieroni, M; Corti, A; Tota, B; Curnis, F; Angelone, T; Colombo, B; Cerra, MC; Bellocci, F; Crea, F; Maseri, A
  • Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart
    Tota, B; Cerra, MC; Gattuso, A
  • Chromogranin A in heart failure; a novel neurohumoral factor and a predictor for mortality
    Ceconi, C; Ferrari, R; Bachetti, T; Opasich, C; Volterrani, M; Colombo, B; Parrinello, G; Corti, A
  • Chromogranin A. Storage and release in hypertension
    Takiyyuddin, MA; Cervenka, JH; Hsiao, RJ; Barbosa, JA; Parmer, RJ; O’Connor, DT
  • Characterization of natural vasostatin-containing peptides in rat heart
    Glattard, E; Angelone, T; Strub, JM; Corti, A; Aunis, D; Tota, B; Metz-Boutigue, MH; Goumon, Y
  • Vasostatin 1 activates eNOS in endothelial cells through a proteoglycan-dependent mechanism
    Ramella, R; Boero, O; Alloatti, G; Angelone, T; Levi, R; Gallo, MP
  • Recombinant N-terminal fragments of chromogranin-A modulate cardiac function of the Langendorff-perfused rat heart
    Cerra, MC; De, IL; Angelone, T; Corti, A; Tota, B
  • Vasostatin-1 stops structural remodeling and improves calcium handling via the eNOS-NO-PKG pathway in rat hearts subjected to chronic beta-adrenergic receptor activation
    Wang, D; Shan, Y; Huang, Y; Tang, Y; Chen, Y; Li, R; Yang, J; Huang, C
  • Endothelium-derived nitric oxide mediates the antiadrenergic effect of human vasostatin-1 in rat ventricular myocardium
    Gallo, MP; Levi, R; Ramella, R; Brero, A; Boero, O; Tota, B; Alloatti, G
  • The vasoinhibitory activity of bovine chromogranin A fragment (vasostatin) and its independence of extracellular calcium in isolated segments of human blood vessels
    Aardal, S; Helle, KB
  • Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
    Pike, SE; Yao, L; Jones, KD; Cherney, B; Appella, E; Sakaguchi, K; Nakhasi, H; Teruya-Feldstein, J; Wirth, P; Gupta, G; Tosato, G
  • Chromogranin/secretogranin proteins in murine heart: myocardial production of chromogranin A fragment catestatin (Chga(364–384))
    Biswas, N; Curello, E; O’Connor, DT; Mahata, SK
  • Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist
    Mahata, SK; O’Connor, DT; Mahata, M; Yoo, SH; Taupenot, L; Wu, H; Gill, BM; Parmer, RJ
  • Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension
    O’Connor, DT; Kailasam, MT; Kennedy, BP; Ziegler, MG; Yanaihara, N; Parmer, RJ
  • Glycosylated chromogranin A in heart failure: implications for processing and cardiomyocyte calcium homeostasis
    Ottesen, AH; Carlson, CR; Louch, WE; Dahl, MB; Sandbu, RA; Johansen, RF; Jarstadmarken, H; Bjoras, M; Hoiseth, AD; Brynildsen, J; Sjaastad, I; Stridsberg, M; Omland, T; Christensen, G; Rosjo, H
  • The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism
    Angelone, T; Quintieri, AM; Brar, BK; Limchaiyawat, PT; Tota, B; Mahata, SK; Cerra, MC
  • Mechanism of cardiovascular actions of the chromogranin A fragment catestatin in vivo
    Kennedy, BP; Mahata, SK; O’Connor, DT; Ziegler, MG
  • Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog
    Mahapatra, NR; O’Connor, DT; Vaingankar, SM; Hikim, AP; Mahata, M; Ray, S; Staite, E; Wu, H; Gu, Y; Dalton, N; Kennedy, BP; Ziegler, MG; Ross, J; Mahata, SK
  • Global disturbances in autonomic function yield cardiovascular instability and hypertension in the chromogranin a null mouse
    Gayen, JR; Gu, Y; O’Connor, DT; Mahata, SK
  • Pathophysiological roles of FGF signaling in the heart
    Itoh, N; Ohta, H
  • Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    Zhang, X; Ibrahimi, OA; Olsen, SK; Umemori, H; Mohammadi, M; Ornitz, DM
  • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    Goetz, R; Beenken, A; Ibrahimi, OA; Kalinina, J; Olsen, SK; Eliseenkova, AV; Xu, C; Neubert, TA; Zhang, F; Linhardt, RJ; Yu, X; White, KE; Inagaki, T; Kliewer, SA; Yamamoto, M; Kurosu, H; Ogawa, Y; Kuro-o, M; Lanske, B; Razzaque, MS; Mohammadi, M
  • Roles of FGF signals in heart development, health, and disease
    Itoh, N; Ohta, H; Nakayama, Y; Konishi, M
  • Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
    Patel, V; Adya, R; Chen, J; Ramanjaneya, M; Bari, MF; Bhudia, SK; Hillhouse, EW; Tan, BK; Randeva, HS
  • Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway
    Zhang, C; Huang, Z; Gu, J; Yan, X; Lu, X; Zhou, S; Wang, S; Shao, M; Zhang, F; Cheng, P; Feng, W; Tan, Y; Li, X
  • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    Badman, MK; Pissios, P; Kennedy, AR; Koukos, G; Flier, JS; Maratos-Flier, E
  • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Inagaki, T; Dutchak, P; Zhao, G; Ding, X; Gautron, L; Parameswara, V; Li, Y; Goetz, R; Mohammadi, M; Esser, V; Elmquist, JK; Gerard, RD; Burgess, SC; Hammer, RE; Mangelsdorf, DJ; Kliewer, SA
  • Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
    Ge, X; Chen, C; Hui, X; Wang, Y; Lam, KS; Xu, A
  • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    Fisher, FM; Kleiner, S; Douris, N; Fox, EC; Mepani, RJ; Verdeguer, F; Wu, J; Kharitonenkov, A; Flier, JS; Maratos-Flier, E; Spiegelman, BM
  • FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    Potthoff, MJ; Inagaki, T; Satapati, S; Ding, X; He, T; Goetz, R; Mohammadi, M; Finck, BN; Mangelsdorf, DJ; Kliewer, SA; Burgess, SC
  • Fibroblast growth factor 21 corrects obesity in mice
    Coskun, T; Bina, HA; Schneider, MA; Dunbar, JD; Hu, CC; Chen, Y; Moller, DE; Kharitonenkov, A
  • FGF21 and cardiac physiopathology
    Planavila, A; Redondo-Angulo, I; Villarroya, F
  • Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
    Brahma, MK; Adam, RC; Pollak, NM; Jaeger, D; Zierler, KA; Pocher, N; Schreiber, R; Romauch, M; Moustafa, T; Eder, S; Ruelicke, T; Preiss-Landl, K; Lass, A; Zechner, R; Haemmerle, G
  • Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart
    Dogan, SA; Pujol, C; Maiti, P; Kukat, A; Wang, S; Hermans, S; Senft, K; Wibom, R; Rugarli, EI; Trifunovic, A
  • Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
    Planavila, A; Redondo, I; Hondares, E; Vinciguerra, M; Munts, C; Iglesias, R; Gabrielli, LA; Sitges, M; Giralt, M; Bilsen, M; Villarroya, F
  • Fibroblast growth factor 21 protects the heart from oxidative stress
    Planavila, A; Redondo-Angulo, I; Ribas, F; Garrabou, G; Casademont, J; Giralt, M; Villarroya, F
  • Musclin, a novel skeletal muscle-derived secretory factor
    Nishizawa, H; Matsuda, M; Yamada, Y; Kawai, K; Suzuki, E; Makishima, M; Kitamura, T; Shimomura, I
  • Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype
    Thomas, G; Moffatt, P; Salois, P; Gaumond, MH; Gingras, R; Godin, E; Miao, D; Goltzman, D; Lanctot, C
  • Osteocrin is a specific ligand of the natriuretic peptide clearance receptor that modulates bone growth
    Moffatt, P; Thomas, G; Sellin, K; Bessette, MC; Lafreniere, F; Akhouayri, O; St-Arnaud, R; Lanctot, C
  • Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Potter, LR; Abbey-Hosch, S; Dickey, DM
  • Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish
    Chiba, A; Watanabe-Takano, H; Terai, K; Fukui, H; Miyazaki, T; Uemura, M; Hashimoto, H; Hibi, M; Fukuhara, S; Mochizuki, N
  • The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury
    Kempf, T; Eden, M; Strelau, J; Naguib, M; Willenbockel, C; Tongers, J; Heineke, J; Kotlarz, D; Xu, J; Molkentin, JD; Niessen, HW; Drexler, H; Wollert, KC
  • Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury
    Oshima, Y; Ouchi, N; Shimano, M; Pimentel, DR; Papanicolaou, KN; Panse, KD; Tsuchida, K; Lara-Pezzi, E; Lee, SJ; Walsh, K
  • Bone morphogenetic protein-2—a potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes
    Tokola, H; Rysa, J; Pikkarainen, S; Hautala, N; Leskinen, H; Kerkela, R; Ilves, M; Aro, J; Vuolteenaho, O; Ritvos, O; Ruskoaho, H
  • Induction of cachexia in mice by systemically administered myostatin
    Zimmers, TA; Davies, MV; Koniaris, LG; Haynes, P; Esquela, AF; Tomkinson, KN; McPherron, AC; Wolfman, NM; Lee, SJ
  • Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure
    Heineke, J; Auger-Messier, M; Xu, J; Sargent, M; York, A; Welle, S; Molkentin, JD
  • GDF15 is a heart-derived hormone that regulates body growth
    Wang, T; Liu, J; McDonald, C; Lupino, K; Zhai, X; Wilkins, BJ; Hakonarson, H; Pei, L
  • Interactions between FGF21 and BMP-2 in osteogenesis
    Ishida, K; Haudenschild, DR
  • Parathyroid hormone-like protein is a secretory product of atrial myocytes
    Deftos, LJ; Burton, DW; Brandt, DW
  • Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2
    Zhang, X; Wang, X; Zhu, H; Kranias, EG; Tang, Y; Peng, T; Chang, J; Fan, GC
  • Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells
    Wang, X; Huang, W; Liu, G; Cai, W; Millard, RW; Wang, Y; Chang, J; Peng, T; Fan, GC
  • MicroRNAs in heart failure: from biomarker to target for therapy
    Vegter, EL; Meer, P; Windt, LJ; Pinto, YM; Voors, AA
  • MicroRNAs: new players in heart failure
    Oliveira-Carvalho, V; Silva, MM; Guimaraes, GV; Bacal, F; Bocchi, EA
  • MicroRNA-133 controls cardiac hypertrophy
    Care, A; Catalucci, D; Felicetti, F; Bonci, D; Addario, A; Gallo, P; Bang, ML; Segnalini, P; Gu, Y; Dalton, ND; Elia, L; Latronico, MV; Hoydal, M; Autore, C; Russo, MA; Dorn, GW; Ellingsen, O; Ruiz-Lozano, P; Peterson, KL; Croce, CM; Peschle, C; Condorelli, G
  • Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure
    Montgomery, RL; Hullinger, TG; Semus, HM; Dickinson, BA; Seto, AG; Lynch, JM; Stack, C; Latimer, PA; Olson, EN; Rooij, E

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