Drug Saf https://doi.org/10.1007/s40264-018-0689-4 SYSTEMATIC REVIEW Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature 1 2,3 4 1,5 1,5 • • • • Clotilde Chatre Franc ¸ois Roubille He ´le `ne Vernhet Christian Jorgensen Yves-Marie Pers Springer International Publishing AG, part of Springer Nature 2018 Abstract MeSH terms. Reports published prior to 31 July, 2017 were Introduction Chloroquine and hydroxychloroquine are eligible for inclusion, without restriction to study design. widely used in the long-term treatment of connective tissue Searches were also conducted on reference lists of included disease and usually considered safe. However, chloro- studies. quine- or hydroxychloroquine-related cardiac disorder is a Results Eighty-six articles were identiﬁed, reporting indi- rare but severe adverse event, which can lead to death. This vidual cases or short series, providing information on 127 systematic review investigates cardiac complications patients (65.4% female). A majority of patients were attributed to chloroquine and hydroxychloroquine. treated with chloroquine (58.3%), with the remaining Methods PubMED, EMBASE, and Cochrane database treated with hydroxychloroquine (39.4%), or both in suc- searches were conducted using keywords derived from cession. Most patients had been treated for a long time (median 7 years, minimum 3 days; maximum 35 years) and
Drug Safety – Springer Journals
Published: Jun 1, 2018
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