Carboxy-methyl cellulose hydrogels used to fill breast implants: a 15-year experience

Carboxy-methyl cellulose hydrogels used to fill breast implants: a 15-year experience Eur J Plast Surg (2001) 24:176 DOI 10.1007/s002380100273 EDIT ORIAL COMMENT Ian T. Jackson · G.-F. Maillard Carboxy-methyl cellulose hydrogels used to fill breast implants: a 15-year experience Published online: 1 August 2001 © Springer-Verlag 2001 Since this paper was sent for publication, the British delivery medicine systems. In addition to this, the French Medical Devices Agency (MDA) have decided to ban MDA (G-med) recently accepted that “New Fill” can be two “hydrogel” prostheses: the PIP hydrogel with hy- used to correct wrinkles. This consists of polylactic acid droxy-methyl cellulose and the NovaGold prosthesis crystals with a hydrogel carmellose. Dow-Corning in with polyvinyl pyrroliodone as a filler. They have ad- 1992 [1], 1993 [2], and 1994 [3] compared the toxicity of vised health authorities, NHS trusts, and primary care silicone gel with carboxy-methyl cellulose and consid- trusts in the United Kingdom not to implant the im- ered this to be a very innocuous material when this com- plants, to identify and isolate all stocks of these implants parison with silicone was made. Therefore it certainly and return them to the suppliers, and also to report any seems as though the carboxy-methyl cellulose of Arion adverse incidence concerning the implanted devices to could be one of the safest implant materials available, but the MDA. of course further investigation is required. It is of interest to note that carboxy-methyl cellulose is a very nontoxic substance because it is also has been used in the food industry for more than 50 years, as well as in References various medications and in subcutaneous implanted long- 1. Siddiqui WH, Schardein JL (1992) Developmental toxicity evaluation of silicone gel and Silastic II mammary envelope implants in rabbits. Toxicology 12:200 This comment refers to the article at 2. Siddiqui WH, Schardein JL (1993) One generation reproduc- s002380100272 tion study of silicone gel and Silastic (trade mark) II mamma- ry envelope implants in rats. Toxicologist 13:75 I.T. Jackson ( ) 3. Siddiqui WH, Schardein JL, Cassidy SL, Meeks RG (1994) Editor-in-Chief Reproductive and developmental toxicity studies of silicone G.-F. Maillard gel Z7–2159A in rats and rabbits. Fundam Appl Toxicol 23: Lausanne, Switzerland 370–376 European Journal of Plastic Surgery Springer Journals

Carboxy-methyl cellulose hydrogels used to fill breast implants: a 15-year experience

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Copyright © 2001 by Springer-Verlag
Medicine & Public Health; Plastic Surgery
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