Carboplatin/paclitaxel

Carboplatin/paclitaxel Reactions 1704, p85 - 2 Jun 2018 Bronchomediastinal fistula: case report The 54-year-old man developed bronchomediastinal fistula during chemotherapy with carboplatin and paclitaxel [taxol] for squamous cell lung cancer. The man, who had squamous cell lung cancer, underwent lower left lobectomy. One year later, he presented recurrence at the ganglion level and received chemotherapy and radiotherapy for three months. After one year of stabilisation, he developed haemoptysis with relapse in the posterior wall of the main right bronchus. Consequently, he was started on carboplatin [route and dosage not stated] and paclitaxel. Approximately one month after the last cycle of chemotherapy, he presented to the emergency department because of progressive dyspnoea and was hospitalised. Radiological findings revealed adenopathic mass- conglomerate of necrotic appearance at the right parahilar and subcarinal mediastinal level along with a fistulous tract that communicated necrotic subcarinal lymphadenopathies with the bronchus intermedius. Flexible bronchoscopy confirmed the neoplastic involvement with broncho-mediastinal fistula in the bronchus intermedius posterior wall. Ten days later, the man’s fistula was sealed by rigid bronchoscope with bovine serum albumin/glutaral under general anaesthesia. During examination, the previous fistulous opening was not visible, which had closed spontaneously. Fourteen days after admission, he was discharged home with clinical improvement; however, he required home oxygen therapy and follow-up by the palliative unit. Two months later, he died at home because of overall deterioration secondary to the evolution of his neoplastic disease. Author comment: "Tracheomediastinal fistulas appear mainly related to lung cancer, and particularly to lymphoma, appearing secondary to necrosis caused by chemotherapy or radiotherapy in adenopathies in close contact with the tracheal wall." Hurtado EJS, et al. Bronchomediastinal fistula with spontaneous resolution in a patient with lung cancer. Current Respiratory Medicine Reviews 13: 178-181, No. 3, Sep 2017. Available from: URL: http:// doi.org/10.2174/1573398X13666170522183920 - Spain 803323129 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Carboplatin/paclitaxel

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
Free
1 page

Loading next page...
1 Page
 
/lp/springer_journal/carboplatin-paclitaxel-xBcW0ie4dP
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46728-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p85 - 2 Jun 2018 Bronchomediastinal fistula: case report The 54-year-old man developed bronchomediastinal fistula during chemotherapy with carboplatin and paclitaxel [taxol] for squamous cell lung cancer. The man, who had squamous cell lung cancer, underwent lower left lobectomy. One year later, he presented recurrence at the ganglion level and received chemotherapy and radiotherapy for three months. After one year of stabilisation, he developed haemoptysis with relapse in the posterior wall of the main right bronchus. Consequently, he was started on carboplatin [route and dosage not stated] and paclitaxel. Approximately one month after the last cycle of chemotherapy, he presented to the emergency department because of progressive dyspnoea and was hospitalised. Radiological findings revealed adenopathic mass- conglomerate of necrotic appearance at the right parahilar and subcarinal mediastinal level along with a fistulous tract that communicated necrotic subcarinal lymphadenopathies with the bronchus intermedius. Flexible bronchoscopy confirmed the neoplastic involvement with broncho-mediastinal fistula in the bronchus intermedius posterior wall. Ten days later, the man’s fistula was sealed by rigid bronchoscope with bovine serum albumin/glutaral under general anaesthesia. During examination, the previous fistulous opening was not visible, which had closed spontaneously. Fourteen days after admission, he was discharged home with clinical improvement; however, he required home oxygen therapy and follow-up by the palliative unit. Two months later, he died at home because of overall deterioration secondary to the evolution of his neoplastic disease. Author comment: "Tracheomediastinal fistulas appear mainly related to lung cancer, and particularly to lymphoma, appearing secondary to necrosis caused by chemotherapy or radiotherapy in adenopathies in close contact with the tracheal wall." Hurtado EJS, et al. Bronchomediastinal fistula with spontaneous resolution in a patient with lung cancer. Current Respiratory Medicine Reviews 13: 178-181, No. 3, Sep 2017. Available from: URL: http:// doi.org/10.2174/1573398X13666170522183920 - Spain 803323129 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off