Reactions 1704, p87 - 2 Jun 2018 Worsening of pleural effusion and increasing respiratory distress: case report A 44-year-old man developed worsening of pleural effusion and increasing respiratory distress during treatment with carboplatin and paclitaxel [dosages and routes not stated]. The man was diagnosed with salivary gland secretory carcinoma and underwent a local excision. He was also found to have ETV6-NTRK3 fusion, CDKN2A/B loss and APC mutation. Two months post-operation, he presented with shortness of breath and increasing cough. He was found to have mediastinal lymphadenopathy, multiple pleural-based nodules and a large pleural effusion, which indicated metastatic disease. Adenocarcinoma was confirmed. He received one cycle of combined chemotherapy with paclitaxel and carboplatin. However, he developed complications of worsening pleural effusions and increasing respiratory distress [times to reactions onsets not stated]. One month after the start of therapy, there was progression in the size and number of pleural metastases. Therefore, the man was initiated on crizotinib during hospitalisation, which resulted in improvement in his respiratory symptoms and tolerance of exertion over the following weeks. After 10 weeks of crizotinib therapy, he returned to the hospital for worsening respiratory distress and was noted to have a progression of disease in the thorax. Thereafter, he died [exact cause of death not stated]. Author comment: "Carboplatin and paclitaxel exacerbated the symptoms". "The patient received one cycle of combined chemotherapy with carboplatin and paclitaxel, which was complicated by worsening pleural effusions, increasing respiratory distress. . ." Cipriani NA, et al. Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib. International Journal of Surgical Pathology 25: 613-618, No. 7, Oct 2017. Available from: URL: http://doi.org/10.1177/1066896917709350 - USA 803322786 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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