Reactions 1704, p87 - 2 Jun 2018
Worsening of pleural effusion and increasing
respiratory distress: case report
A 44-year-old man developed worsening of pleural effusion
and increasing respiratory distress during treatment with
carboplatin and paclitaxel [dosages and routes not stated].
The man was diagnosed with salivary gland secretory
carcinoma and underwent a local excision. He was also found
to have ETV6-NTRK3 fusion, CDKN2A/B loss and APC
mutation. Two months post-operation, he presented with
shortness of breath and increasing cough. He was found to
have mediastinal lymphadenopathy, multiple pleural-based
nodules and a large pleural effusion, which indicated
metastatic disease. Adenocarcinoma was confirmed. He
received one cycle of combined chemotherapy with paclitaxel
and carboplatin. However, he developed complications of
worsening pleural effusions and increasing respiratory distress
[times to reactions onsets not stated]. One month after the
start of therapy, there was progression in the size and number
of pleural metastases.
Therefore, the man was initiated on crizotinib during
hospitalisation, which resulted in improvement in his
respiratory symptoms and tolerance of exertion over the
following weeks. After 10 weeks of crizotinib therapy, he
returned to the hospital for worsening respiratory distress and
was noted to have a progression of disease in the thorax.
Thereafter, he died [exact cause of death not stated].
Author comment: "Carboplatin and paclitaxel exacerbated
the symptoms". "The patient received one cycle of combined
chemotherapy with carboplatin and paclitaxel, which was
complicated by worsening pleural effusions, increasing
respiratory distress. . ."
Cipriani NA, et al. Salivary Gland Secretory Carcinoma With High-Grade
Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained
Response to Crizotinib. International Journal of Surgical Pathology 25: 613-618,
No. 7, Oct 2017. Available from: URL: http://doi.org/10.1177/1066896917709350
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved