Reactions 1680, p80 - 2 Dec 2017
Generalised tonic clonic seizures and status
epilepticus: case report
A 5-year-old boy developed generalised tonic clonic
seizures and status epilepticus following an accidental
overdose of carbamazepine.
The previously nonepileptic boy presented to a casualty
department with generalised tonic-clonic status [time to
reaction onset not stated]. In view of emergency management,
he received treatment with midazolam injection followed by
valproic acid IV. His father informed that the patient
accidentally ingested five tablets of carbamazepine 200mg,
which were prescribed for his grandfather. At the presentation,
he appeared drowsy, and was electively intubated for
protection his airway.
The boy was treated with midazolam for his continued
status epilepticus. He underwent gastric lavage as his blood
carbamazepine level was found to be above therapeutic range.
He was evaluated with EEG, which revealed a diffuse slowing.
His seizures ceased in six hours with improvement in his
sensorium over the next 24 hours. He was continued on slowly
tapering midazolam, and was discharged after five days.
Author comment: "[I]t is clear that some AEDs such as
carbamazepine have the potential to cause aggravation of
existing condition and even development of new episode of
seizure in neurologically normal children." "Our case,
however, presented with generalized tonic–clonic seizures
due to carbamazepine toxicity."
Benny R, et al. Carbamazepine-induced seizure in a nonepileptic child. Annals of
Indian Academy of Neurology 20: 432-434, No. 4, 2017. Available from: URL:
http://doi.org/10.4103/aian.AIAN_169_17 - India
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved