Carbamazepine/levetiracetam/phenobarbital/CNP Reactions 1680, p81 - 2 Dec 2017 Carbamazepine/levetiracetam/ phenobarbital/CNP Unilateral congenital glaucoma: case report An infant described in International Registry of Antiepileptic Drugs and Pregnancy (EURAP) developed unilateral congenital glaucoma following in-utero exposure to carbamazepine, levetiracetam, phenobarbital and CNP [specific drug not stated; exact age, sex, dosage, route, time to reaction onset and outcome not stated]. The infant’s mother aged 28 years received vagus nerve stimulation (VNS) and carbamazepine, levetiracetam, phenobarbital and CNP for epilepsy. Eventually, an infant was born after gestational period of 36.6 weeks by normal delivery with a major malformation i.e. unilateral congenital glaucoma. Author comment: "One infant (3.9%; 95% CI 0.1%–19.6%) was born with a major malformation (unilateral congenital glaucoma), which is within the range expected among offspring of [antiepileptic drug]-treated women." Sabers A, et al. Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy. Epilepsy Research 137: 159-162, Nov 2017. Available from: URL: - Denmark 803284065 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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