Reactions 1680, p81 - 2 Dec 2017
Unilateral congenital glaucoma: case report
An infant described in International Registry of Antiepileptic
Drugs and Pregnancy (EURAP) developed unilateral congenital
glaucoma following in-utero exposure to carbamazepine,
levetiracetam, phenobarbital and CNP [specific drug not
stated; exact age, sex, dosage, route, time to reaction onset and
outcome not stated].
The infant’s mother aged 28 years received vagus nerve
stimulation (VNS) and carbamazepine, levetiracetam,
phenobarbital and CNP for epilepsy. Eventually, an infant was
born after gestational period of 36.6 weeks by normal delivery
with a major malformation i.e. unilateral congenital glaucoma.
Author comment: "One infant (3.9%; 95% CI
0.1%–19.6%) was born with a major malformation (unilateral
congenital glaucoma), which is within the range expected
among offspring of [antiepileptic drug]-treated women."
Sabers A, et al. Maternal and fetal outcomes associated with vagus nerve
stimulation during pregnancy. Epilepsy Research 137: 159-162, Nov 2017.
Available from: URL: http://doi.org/10.1016/j.eplepsyres.2017.05.013 -
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved