Caraparu virus induces damage and alterations in antioxidant defenses in the liver of BALB/c mice after subcutaneous infection

Caraparu virus induces damage and alterations in antioxidant defenses in the liver of BALB/c mice... Oxidative stress is a disturbance in the oxidant-antioxidant balance leading to potential cellular damage. Most cells can tolerate a mild degree of oxidative stress because they have a system that counteracts oxidation that includes antioxidant molecules such as glutathione (GSH) and superoxide dismutase (SOD). Disruption of the host antioxidant status has been recognized as an important contributor to the pathogenesis of many viruses. Caraparu virus (CARV) is a member of group C of the Bunyaviridae family of viruses. In South American countries, group C bunyaviruses are among the common agents of human febrile illness and have caused multiple notable outbreaks of human disease in recent decades; nevertheless, little is known about the pathogenic characteristics of these viruses. The purpose of this study was to examine the hepatic pathogenesis of CARV in mice and the involvement of oxidative stress and antioxidant defenses on this pathology. Following subcutaneous infection of BALB/c mice, CARV was detected in the liver, and histopathology revealed acute hepatitis. Increased serum levels of aspartate and alanine aminotransferases (AST/ALT) and greater hepatic expression of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) were found in infected animals. CARV infection did not alter the biomarkers of oxidative stress but caused an increase in GSH content and altered the expression and activity of SOD. This is the first report of an alteration of oxidative homeostasis upon CARV infection, which may, in part, explain the hepatic pathogenesis of this virus, as well as the pathogenesis of other Bunyaviridae members. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Caraparu virus induces damage and alterations in antioxidant defenses in the liver of BALB/c mice after subcutaneous infection

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2123-2
Publisher site
See Article on Publisher Site

References

  • Microsomal lipid peroxidation
    Buege, JA; Aust, SD
  • Identification of a phylogenetically distinct orthobunyavirus from group C
    Brito Magalhães, CL; Drumond, BP; Novaes, RF; Quinan, BR; Magalhães, JC; Santos, JR; Pinto, CA; Assis, MT; Bonjardim, CA; Kroon, EG; Ferreira, PC
  • Redox regulatory mechanisms of cellular signal transduction
    Gabbita, SP; Robinson, KA; Stewart, CA; Floyd, RA; Hensley, K
  • Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice
    Huang, SH; Cao, XJ; Liu, W; Shi, XY; Wei, W
  • Monitoring disulfide bond formation in the eukaryotic cytosol
    Ostergaard, H; Tachibana, C; Winther, JR

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