Mammalian Genome 10, 318–321 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Capn7: A highly divergent vertebrate calpain with a novel C-terminal domain 1 2 1 1 Tanna Franz, Martin Vingron, Thomas Boehm, T. Neil Dear Max-Planck Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany German Cancer Research Center, Im Neuenheimerfeld 280, D-69120 Heidelberg, Germany Received: 12 August 1998 / Accepted: 15 October 1998 The first identified calpains constituted a family of intracellular the calmodulin-like domain IV of the ‘traditional’ calpains or 2+ Ca -dependent cysteine proteases that have been associated with to the domain T of CAPN5 and CAPN6. A search using the a wide variety of physiological processes and pathological condi- PROSITE database at the European Bioinformatics Institute 2+ tions (Sorimachi et al. 1997; Suzuki et al. 1995). In vertebrates, (www.ebi.ac.uk) did not reveal any putative EF-hand (Ca - eight different members of this family have been identified: the binding) domains in the protein. We have termed the gene Capn7 ubiquitous m (CAPN1), m (CAPN2), m/m, and the tissue-specific in accordance with the approved mouse nomenclature, and the p94 (CAPN3), nCL-2 (CAPN4), CAPN5, CAPN6, and nCL-4 cal- novel C-terminal domain, domain N. Phylogenetic analysis of
Mammalian Genome – Springer Journals
Published: Mar 1, 1999
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