Capecitabine/oxaliplatin

Capecitabine/oxaliplatin Reactions 1704, p79 - 2 Jun 2018 Phrenic nerve paralysis and peripheral neuropathy: case report A 66-year-old man developed phrenic nerve paralysis and grade II peripheral neuropathy while receiving chemotherapy with capecitabine and oxaliplatin [dosages not stated; not all routes and durations of treatments to reactions onsets stated]. The man was diagnosed with sigmoid colon cancer with infiltration to the urinary bladder. In May 2015, he underwent colectomy of the sigmoid colon and partial cystectomy of the bladder. Subsequently, he started receiving adjunctive chemotherapy with oral capecitabine and oxaliplatin for the stage II cancer. However, during the therapy, he developed grade II peripheral neuropathy and phrenic nerve paralysis. Therefore, doses of capecitabine and oxaliplatin were decreased to 80% from the third cycle. Additionally, after completion of the seventh cycle 7, he developed disturbed breathing and cough. Chest CT scan revealed elevated right diaphragm along with zosteroid changes in the medial lobe of the right lung secondary to discoid atelectatic condition, but drug induced interstitial pneumonia was not considered. As th the respiratory symptoms were mild, the 8 cycle was administered. Two weeks after completion of the capecitabine administration, the symptoms disappeared along with recovery of the diaphragm to its original height. During follow up examination at two months, recurrent lesions or breathing difficulties were not noted. It was considered that both the peripheral neuropathy and phrenic nerve paralysis occurred due the treatment with oxaliplatin and capecitabine. Author comment: "It is unknown whether phrenic nerve paralysis occurs. However, because other organic lesions were absent and the symptoms appeared during chemotherapy, the possibility is not deniable." "Because Grade 2 peripheral neuropathy appeared as a side effect, the dose was decreased to 80% from the 3 cycle." Yabe N, et al. [A Case of Phrenic Nerve Paralysis During Adjuvant Chemotherapy for Rectal Cancer]. [Japanese]. Gan to Kagaku Ryoho 44: 1916-1918, No. 12, Nov 2017 [Japanese; summarised from an English abstract] - Japan 803322779 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Capecitabine/oxaliplatin

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/capecitabine-oxaliplatin-xS5jtZX3CQ
Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46722-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p79 - 2 Jun 2018 Phrenic nerve paralysis and peripheral neuropathy: case report A 66-year-old man developed phrenic nerve paralysis and grade II peripheral neuropathy while receiving chemotherapy with capecitabine and oxaliplatin [dosages not stated; not all routes and durations of treatments to reactions onsets stated]. The man was diagnosed with sigmoid colon cancer with infiltration to the urinary bladder. In May 2015, he underwent colectomy of the sigmoid colon and partial cystectomy of the bladder. Subsequently, he started receiving adjunctive chemotherapy with oral capecitabine and oxaliplatin for the stage II cancer. However, during the therapy, he developed grade II peripheral neuropathy and phrenic nerve paralysis. Therefore, doses of capecitabine and oxaliplatin were decreased to 80% from the third cycle. Additionally, after completion of the seventh cycle 7, he developed disturbed breathing and cough. Chest CT scan revealed elevated right diaphragm along with zosteroid changes in the medial lobe of the right lung secondary to discoid atelectatic condition, but drug induced interstitial pneumonia was not considered. As th the respiratory symptoms were mild, the 8 cycle was administered. Two weeks after completion of the capecitabine administration, the symptoms disappeared along with recovery of the diaphragm to its original height. During follow up examination at two months, recurrent lesions or breathing difficulties were not noted. It was considered that both the peripheral neuropathy and phrenic nerve paralysis occurred due the treatment with oxaliplatin and capecitabine. Author comment: "It is unknown whether phrenic nerve paralysis occurs. However, because other organic lesions were absent and the symptoms appeared during chemotherapy, the possibility is not deniable." "Because Grade 2 peripheral neuropathy appeared as a side effect, the dose was decreased to 80% from the 3 cycle." Yabe N, et al. [A Case of Phrenic Nerve Paralysis During Adjuvant Chemotherapy for Rectal Cancer]. [Japanese]. Gan to Kagaku Ryoho 44: 1916-1918, No. 12, Nov 2017 [Japanese; summarised from an English abstract] - Japan 803322779 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off