Reactions 1704, p79 - 2 Jun 2018 Phrenic nerve paralysis and peripheral neuropathy: case report A 66-year-old man developed phrenic nerve paralysis and grade II peripheral neuropathy while receiving chemotherapy with capecitabine and oxaliplatin [dosages not stated; not all routes and durations of treatments to reactions onsets stated]. The man was diagnosed with sigmoid colon cancer with infiltration to the urinary bladder. In May 2015, he underwent colectomy of the sigmoid colon and partial cystectomy of the bladder. Subsequently, he started receiving adjunctive chemotherapy with oral capecitabine and oxaliplatin for the stage II cancer. However, during the therapy, he developed grade II peripheral neuropathy and phrenic nerve paralysis. Therefore, doses of capecitabine and oxaliplatin were decreased to 80% from the third cycle. Additionally, after completion of the seventh cycle 7, he developed disturbed breathing and cough. Chest CT scan revealed elevated right diaphragm along with zosteroid changes in the medial lobe of the right lung secondary to discoid atelectatic condition, but drug induced interstitial pneumonia was not considered. As th the respiratory symptoms were mild, the 8 cycle was administered. Two weeks after completion of the capecitabine administration, the symptoms disappeared along with recovery of the diaphragm to its original height. During follow up examination at two months, recurrent lesions or breathing difficulties were not noted. It was considered that both the peripheral neuropathy and phrenic nerve paralysis occurred due the treatment with oxaliplatin and capecitabine. Author comment: "It is unknown whether phrenic nerve paralysis occurs. However, because other organic lesions were absent and the symptoms appeared during chemotherapy, the possibility is not deniable." "Because Grade 2 peripheral neuropathy appeared as a side effect, the dose was decreased to 80% from the 3 cycle." Yabe N, et al. [A Case of Phrenic Nerve Paralysis During Adjuvant Chemotherapy for Rectal Cancer]. [Japanese]. Gan to Kagaku Ryoho 44: 1916-1918, No. 12, Nov 2017 [Japanese; summarised from an English abstract] - Japan 803322779 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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