Reactions 1680, p79 - 2 Dec 2017
Pyogenic granuloma: case report
A 73-year-old man developed pyogenic granuloma during
treatment with capecitabine and oxaliplatin.
The man, who was diagnosed with adenocarcinoma of the
gastroesophageal junction, started receiving combination
therapy with capecitabine and oxaliplatin [route and dosage
not stated]. One week after the start of treatment, the skin
nodules appeared on his fingers. He was referred for
assessment of haemorrhagic nodules appeared on his fingers.
He had no history of trauma. Physical examination revealed a
pale-reddish, dome-shaped, 5mm nodules on the index
fingers and left thumb. Additionally, palmar erythema with
tingling sensation was reported.
The man’s nodules appearing on his fingers were removed
surgically. A histopathological study showed presence of well-
circumscribed proliferation of small capillaries in a lobular
fashion in the dermis. Based on the medical history and these
findings, he was diagnosed with pyogenic granulomas caused
due to capecitabine therapy. No reappearance was seen three
months after resection.
Author comment: ’’Our patient noted the lesions
approximately 1 week after the treatment, suggesting that
[pyogenic granulomas]/[pyogenic granulomas]-like lesions
might have developed in a relatively short period of time after
the administration of capecitabine. Although we could find
no report of [pyogenic granulomas] caused by oxaliplatin, we
cannot exclude the possibility of oxaliplatin as a responsible
Fujiwara C, et al. Pyogenic granuloma possibly associated with capecitabine
therapy. Journal of Dermatology 44: 1329-1331, No. 11, Nov 2017. Available
from: URL: http://doi.org/10.1111/1346-8138.13691 - Japan
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved