Curr Stem Cell Rep (2017) 3:240–247 DOI 10.1007/s40778-017-0095-3 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) 1 1,2 Farinaz Forouzannia & Sivabal Sivaloganathan Published online: 15 July 2017 Springer International Publishing AG 2017 Abstract physical experiments that eventually lead to the resolution of Purpose of Review Putative studies continue to support the this very problem. assertion of the cancer stem cell (CSC) hypothesis, namely Summary In this paper, we review mathematical models that that a very small subgroup of a malignant tumor population explore the role of CSCs in treatment response, in developing initiates and drives tumor growth. These cells are purported to chemo and radio resistance, as well as those that suggest new possess similar biological properties to their normal adult stem treatment strategies. In addition, mathematical models that cell counterparts. The CSC hypothesis arises from the obser- focus on optimal therapeutic protocols will also be discussed. vation that tumors like normal tissues have their origin in cells . . that display potential for self-renewal as well as the ability to Keywords Cancer stem cells Heterogeneity Mathematical . . . generate differentiated cells of various lineages. In addition, models Treatment response Resistance Targeted therapy CSCs have
Current Stem Cell Reports – Springer Journals
Published: Jul 15, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera