Cancer Stem Cells, the Tipping Point: Minority Rules?

Cancer Stem Cells, the Tipping Point: Minority Rules? Curr Stem Cell Rep (2017) 3:240–247 DOI 10.1007/s40778-017-0095-3 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) 1 1,2 Farinaz Forouzannia & Sivabal Sivaloganathan Published online: 15 July 2017 Springer International Publishing AG 2017 Abstract physical experiments that eventually lead to the resolution of Purpose of Review Putative studies continue to support the this very problem. assertion of the cancer stem cell (CSC) hypothesis, namely Summary In this paper, we review mathematical models that that a very small subgroup of a malignant tumor population explore the role of CSCs in treatment response, in developing initiates and drives tumor growth. These cells are purported to chemo and radio resistance, as well as those that suggest new possess similar biological properties to their normal adult stem treatment strategies. In addition, mathematical models that cell counterparts. The CSC hypothesis arises from the obser- focus on optimal therapeutic protocols will also be discussed. vation that tumors like normal tissues have their origin in cells . . that display potential for self-renewal as well as the ability to Keywords Cancer stem cells Heterogeneity Mathematical . . . generate differentiated cells of various lineages. In addition, models Treatment response Resistance Targeted therapy CSCs have Current Stem Cell Reports Springer Journals

Cancer Stem Cells, the Tipping Point: Minority Rules?

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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Life Sciences; Cell Biology; Stem Cells
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