Diabetologia (2017) 60:1691–1703 DOI 10.1007/s00125-017-4312-5 ARTICLE Cancer risk among insulin users: comparing analogues with human insulin in the CARING five-country cohort study 1 2,3 2 4 Anna But & Marie L. De Bruin & Marloes T. Bazelier & Vidar Hjellvik & 5,6,7 8 9 Morten Andersen & Anssi Auvinen & Jakob Starup-Linde & 10,11 4 2,12,13,14 Marjanka K. Schmidt & Kari Furu & Frank de Vries & 4 5 1 Øystein Karlstad & Nils Ekström & Jari Haukka Received: 13 December 2016 /Accepted: 24 April 2017 /Published online: 1 June 2017 The Author(s) 2017. This article is an open access publication Abstract regression models. For each of ten cancer sites studied, we Aims/hypothesis The aim of this work was to investigate the estimated the rate ratios (RRs) by duration (≤0.5, 0.5–1, 1–2, relationship between use of certain insulins and risk for cancer, 2–3, 3–4, 4–5, 5–6 and >6 years) of cumulative exposure to when addressing the limitations and biases involved in previ- insulin glargine or insulin detemir relative to that of human ous studies. insulin. Methods National Health Registries from Denmark Results A total of 21,390 cancer cases occurred during a mean (1996–2010), Finland (1996–2011), Norway (2005–2010) follow-up of
Diabetologia – Springer Journals
Published: Jun 1, 2017
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