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Cancer incidence in a cohort of asbestos-exposed workers undergoing health surveillance

Cancer incidence in a cohort of asbestos-exposed workers undergoing health surveillance Objectives To compare a local cohort of 2488 men occupationally exposed to asbestos and enrolled in a public health sur- veillance program with the 1995–2009 cancer incidence of the general population of Friuli Venezia Giulia (FVG) region, Northeast Italy, we conducted a historical cohort study. Methods Standardized incidence ratios (SIRs), with 95% confidence interval (95% CI), for specific cancer sites were esti- mated in the cohort and in subgroups of workers employed in shipbuilding between 1974 and 1994. For internal comparisons, we calculated incidence rate ratios (IRRs) for all cancers, lung cancer and mesothelioma, by level of exposure to asbestos and sector of employment adjusted for smoking habits and age at start of follow-up. Results Among cohort members the SIR was 8.82 (95% CI 5.95–12.61) for mesothelioma and 1.61 (95% CI 1.26–2.04) for lung cancer. In subgroup analyses, the SIR for lung cancer in subjects hired in shipbuilding between 1974 and 1984 was 2.09 (95% CI 1.32–3.13). In the overall cohort, a borderline increased incidence was also found for stomach cancer (SIR = 1.53 95% CI 0.96–2.31). Internal comparisons within the cohort show that among men with high asbestos exposure level the relative risk was almost threefold for lung http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Archives of Occupational and Environmental Health Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Environment; Environmental Health; Rehabilitation; Occupational Medicine/Industrial Medicine
ISSN
0340-0131
eISSN
1432-1246
DOI
10.1007/s00420-018-1326-3
Publisher site
See Article on Publisher Site

Abstract

Objectives To compare a local cohort of 2488 men occupationally exposed to asbestos and enrolled in a public health sur- veillance program with the 1995–2009 cancer incidence of the general population of Friuli Venezia Giulia (FVG) region, Northeast Italy, we conducted a historical cohort study. Methods Standardized incidence ratios (SIRs), with 95% confidence interval (95% CI), for specific cancer sites were esti- mated in the cohort and in subgroups of workers employed in shipbuilding between 1974 and 1994. For internal comparisons, we calculated incidence rate ratios (IRRs) for all cancers, lung cancer and mesothelioma, by level of exposure to asbestos and sector of employment adjusted for smoking habits and age at start of follow-up. Results Among cohort members the SIR was 8.82 (95% CI 5.95–12.61) for mesothelioma and 1.61 (95% CI 1.26–2.04) for lung cancer. In subgroup analyses, the SIR for lung cancer in subjects hired in shipbuilding between 1974 and 1984 was 2.09 (95% CI 1.32–3.13). In the overall cohort, a borderline increased incidence was also found for stomach cancer (SIR = 1.53 95% CI 0.96–2.31). Internal comparisons within the cohort show that among men with high asbestos exposure level the relative risk was almost threefold for lung

Journal

International Archives of Occupational and Environmental HealthSpringer Journals

Published: Jun 5, 2018

References