Curr Oncol Rep (2017) 19:66 DOI 10.1007/s11912-017-0625-2 EVOLVING THERAPIES (R BUKOWSKI, SECTION EDITOR) Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics 1,2 1 1,3 Jonathan L. Messerschmidt & Prianka Bhattacharya & Gerald L. Messerschmidt Springer Science+Business Media, LLC 2017 Abstract survival traits within various cancer clones. Hundreds of mu- Purpose of Review The knowledge base of malignant cell tations have been identified in single individual cancers, but growth and resulting targets is rapidly increasing every day. spread across many clones in the patient’s body. Precision Clonal theory is essential to understand the changes required oncology will require accurate measurement of these cancer for a cell to become malignant. These changes are then clues survival-benefiting mutations to develop strategies for effec- to therapeutic intervention strategies. Immune system optimi- tive therapy. Inhibiting these cellular mechanisms is a first zation is a critical piece to find, recognize, and eliminate all step, but these malignant cells need to be eliminated by the cancer cells from the host. Only by administering (1) multiple host’s mechanisms, which we are learning to direct more therapies that counteract the cancer cell’s mutational and ex- specifically. ternally induced survival traits and (2) by
Current Oncology Reports – Springer Journals
Published: Aug 12, 2017
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