Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics

Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics Curr Oncol Rep (2017) 19:66 DOI 10.1007/s11912-017-0625-2 EVOLVING THERAPIES (R BUKOWSKI, SECTION EDITOR) Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics 1,2 1 1,3 Jonathan L. Messerschmidt & Prianka Bhattacharya & Gerald L. Messerschmidt Springer Science+Business Media, LLC 2017 Abstract survival traits within various cancer clones. Hundreds of mu- Purpose of Review The knowledge base of malignant cell tations have been identified in single individual cancers, but growth and resulting targets is rapidly increasing every day. spread across many clones in the patient’s body. Precision Clonal theory is essential to understand the changes required oncology will require accurate measurement of these cancer for a cell to become malignant. These changes are then clues survival-benefiting mutations to develop strategies for effec- to therapeutic intervention strategies. Immune system optimi- tive therapy. Inhibiting these cellular mechanisms is a first zation is a critical piece to find, recognize, and eliminate all step, but these malignant cells need to be eliminated by the cancer cells from the host. Only by administering (1) multiple host’s mechanisms, which we are learning to direct more therapies that counteract the cancer cell’s mutational and ex- specifically. ternally induced survival traits and (2) by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Oncology Reports Springer Journals

Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Oncology
ISSN
1523-3790
eISSN
1534-6269
D.O.I.
10.1007/s11912-017-0625-2
Publisher site
See Article on Publisher Site

Abstract

Curr Oncol Rep (2017) 19:66 DOI 10.1007/s11912-017-0625-2 EVOLVING THERAPIES (R BUKOWSKI, SECTION EDITOR) Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics 1,2 1 1,3 Jonathan L. Messerschmidt & Prianka Bhattacharya & Gerald L. Messerschmidt Springer Science+Business Media, LLC 2017 Abstract survival traits within various cancer clones. Hundreds of mu- Purpose of Review The knowledge base of malignant cell tations have been identified in single individual cancers, but growth and resulting targets is rapidly increasing every day. spread across many clones in the patient’s body. Precision Clonal theory is essential to understand the changes required oncology will require accurate measurement of these cancer for a cell to become malignant. These changes are then clues survival-benefiting mutations to develop strategies for effec- to therapeutic intervention strategies. Immune system optimi- tive therapy. Inhibiting these cellular mechanisms is a first zation is a critical piece to find, recognize, and eliminate all step, but these malignant cells need to be eliminated by the cancer cells from the host. Only by administering (1) multiple host’s mechanisms, which we are learning to direct more therapies that counteract the cancer cell’s mutational and ex- specifically. ternally induced survival traits and (2) by

Journal

Current Oncology ReportsSpringer Journals

Published: Aug 12, 2017

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