Vectors derived from the adeno-associated viruses (AAV) have been successfully used for the long-term expression of therapeutic genes in animal models and in patients. Stable expression of the transgene in the transduced cells can be used to correct disease stemming from genetic deficiencies. One of the major advantages of these vectors is reported to be the absence of deleterious immune responses following gene transfer. However, recent studies have shown that AAV vectors elicit humoral and cellular responses against the transgene products. This review article will focus on these two unique yet converse aspects of AAV: the ability to elicit host immune response to destroy target cells containing the transduced protein and the ability to evade immune response leading to stable expression of the transduced genes.
Archives of Virology – Springer Journals
Published: Aug 1, 2003
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud