Ca2+-activated nonselective cation channels in rat neonatal atrial myocytes

Ca2+-activated nonselective cation channels in rat neonatal atrial myocytes A nonselective cation channel activated by intracellular Ca2+ was identified in inside-out membrane patches taken from cultured rat atrial myocytes. Ca2+ (0.01-1.00 mM) reversibly activated the channel in a concentration-dependent manner. The channel often showed a quick and irreversible rundown within a few minutes after patch excision. The I-V relationship of the channel was linear between-100 and +100 mV. The single channel conductance was 26.0 ± 0.5 pS and its open probability was weakly voltage-dependent. Ion-substitution experiments showed that the channel was permeable to monovalent cations (P x /P Cs : Li+ (1.5) = K+ (1.5)> Na+ (1.2) > Rb+ (1.1) > Cs+ (1.0)) but not to Cl- (PCl/PCs < 0.01) and Ca2+ (PCa/PCs =0.02 ± 0.01). The Journal of Membrane Biology Springer Journals

Ca2+-activated nonselective cation channels in rat neonatal atrial myocytes

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Copyright © 2003 by Springer-Verlag
Life Sciences; Biochemistry, general; Human Physiology
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