C. difficile Infection in Children: What’s New?

C. difficile Infection in Children: What’s New? Purpose of review The purpose of this review is to present the epidemiology of Clostridium difficile infection in children and to present a number of clinical challenges in diagnosis and therapy that are unique to the pediatric population. Recent findings Current research has focused on novel methods of prevention and treat- ment of C. difficile infection in children. Fecal microbial transplantation (FMT) for recurrent C. difficile is increasingly prescribed for children, and recent data includes comparisons of effectiveness and tolerability between methods of delivery. Summary The incidence of C. difficile infection in children has risen in recent decades both in healthy children and those with underlying comorbidities. Antibiotic use, acid suppres- sive medication use, and the presence of enteric feeding tubes are well-documented risk factors. There is no standard method of testing for C. difficile infection in children, which complicates epidemiological tracking and detection of active disease versus asymptomatic colonization. First-line therapy for initial infection in children is metronidazole, while vancomycin may be reserved for those with severe infection or high risk of complications. Recurrence of infection is frequent, and while repeat courses of antibiotics may be effective, fecal microbial transplant should be considered a safe and efficacious alternative http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Treatment Options in Pediatrics Springer Journals

C. difficile Infection in Children: What’s New?

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pediatrics; General Practice / Family Medicine; Intensive / Critical Care Medicine; Maternal and Child Health
eISSN
2198-6088
D.O.I.
10.1007/s40746-018-0124-1
Publisher site
See Article on Publisher Site

Abstract

Purpose of review The purpose of this review is to present the epidemiology of Clostridium difficile infection in children and to present a number of clinical challenges in diagnosis and therapy that are unique to the pediatric population. Recent findings Current research has focused on novel methods of prevention and treat- ment of C. difficile infection in children. Fecal microbial transplantation (FMT) for recurrent C. difficile is increasingly prescribed for children, and recent data includes comparisons of effectiveness and tolerability between methods of delivery. Summary The incidence of C. difficile infection in children has risen in recent decades both in healthy children and those with underlying comorbidities. Antibiotic use, acid suppres- sive medication use, and the presence of enteric feeding tubes are well-documented risk factors. There is no standard method of testing for C. difficile infection in children, which complicates epidemiological tracking and detection of active disease versus asymptomatic colonization. First-line therapy for initial infection in children is metronidazole, while vancomycin may be reserved for those with severe infection or high risk of complications. Recurrence of infection is frequent, and while repeat courses of antibiotics may be effective, fecal microbial transplant should be considered a safe and efficacious alternative

Journal

Current Treatment Options in PediatricsSpringer Journals

Published: Apr 23, 2018

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