Busulfan/cyclophosphamide Reactions 1680, p74 - 2 Dec 2017 Hepatitis B reactivation syndrome: case report A 45-year-old woman developed hepatitis B reactivation syndrome following treatment with busulfan and cyclophosphamide [dosages, routes and time to reaction onset not stated]. The woman was diagnosed with Durie-Salmon Stage II International Staging System II multiple myeloma, in June 1998. She received an allograft transplant in December 1998. Subsequently, she received conditioning therapy with busulfan, cyclophosphamide and total bone marrow irradiation. Post-transplant and the busulfan and cyclophosphamide immunosuppressant therapy, she developed hepatitis B reactivation syndrome. The woman was treated successfully with lamivudine. She developed recurrent extra-medullary plasmacytomas in the breast and right atrium of the heart 11 years and 13 years after the allograft transplant, respectively. Author comment: "The posttransplant course was rather uneventful except for a hepatitis B reactivation syndrome (after immunosuppressant therapy) successfully treated with lamivudine." Stawis AN, et al. Recurrent plasmacytomas after allografting in a patient with multiple myeloma. Case Reports in Medicine 2012: 2012. Available from: URL: http://doi.org/10.1155/2012/168785 - USA 803284649 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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