Buprenorphine/naltrexone interaction

Buprenorphine/naltrexone interaction Reactions 1680, p73 - 2 Dec 2017 X S Opioid withdrawal symptoms due to inadvertent administration of naltrexone: case report A 58-year-old man inadvertently received naltrexone leading to opioid withdrawal symptoms following concomitant administration of naltrexone and buprenorphine. The man had a history of antisocial personality disorder, alcohol use disorder and heroin use disorder. Buprenorphine was started 10 year ago at a dose of 16 mg/day [route not stated] and heroin was discontinued since then. He gradually developed alcohol dependence and smoked cannabis occasionally. For residential alcohol detoxification, he was hospitalised. He was scheduled to receive diazepam for 12 days. On hospital day 10, he mistakenly received 50mg naltrexone tablet along with other treatment medications including 8mg of buprenorphine. The next hour, he developed opioid withdrawal symptoms comprising of confusion, rhinorrhoea, mydriasis, muscle pain, agitation, tachycardia and increased BP. The man was treated with diazepam and phloroglucinol without any improvement. Two hours after the administration of naltrexone tablet, a decision was made to administer additional 8mg of buprenorphine. Within the next hours, the withdrawal symptoms resolved completely. On day 19, he was discharged. Author comment: ’’On the10th day of hospitalization, he was mistakenly given 50 mg naltrexone, together with the rest of his treatment, which included the 8 mg buprenorphine. In the following hour, he displayed severe opioid withdrawal symptoms’’. Lescut C, et al. Naltrexone- or Nalmefene-Related Buprenorphine Withdrawal: Treat It With More Buprenorphine. Journal of Clinical Psychopharmacology 37: 631-633, No. 5, Oct 2017. Available from: URL: http://doi.org/10.1097/ JCP.0000000000000763 - France 803283902 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Buprenorphine/naltrexone interaction

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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