Budesonide

Budesonide Reactions 1704, p73 - 2 Jun 2018 Oesophageal actinomycosis: case report A 30-year-old man developed of oesophageal actinomycosis following prolonged treatment with budesonide [time to reaction onset not clearly stated]. The man, who had a history of hyperuricaemia and allergic asthma, presented with dysphagia for solids. He had received budesonide inhalations 200 400 µg/day continuously for a period of up to 2 years in a row. The budesonide treatment had been stopped from more than 3 years, and he was currently using terbutaline only. Gastroscopy revealed light rings in the distal third and fine longitudinal striations, indicating eosinophilic oesophagitis. He also showed a small sliding hiatal hernia. The biopsy findings reveled oesophageal epithelium with eosinophilic infiltrate, compatible with eosinophilic oesophagitis and colonies of actinomyces germs on the surface were observed. The man was treated with doxycycline for 4 weeks and showed clinical improvement in dysphagia; however, no complete resolution of symptoms occurred. Five months later, gastroscopy revealed signs of eosinophilic oesophagitis, whitish exudates and presence of the concentric rings. The biopsy confirmed eosinophilic oesophagitis, with no actinomyces colonies. Subsequently, he received treatment with omeprazole and fluticasone propionate [fluticasone] for eosinophilic oesophagitis. Despite a clinical improvement with treatment, he presented with self-limiting isolated episodes of dysphagia, for which a new endoscopic exploration was conducted one year later. Endoscopic signs of eosinophilic oesophagitis were observed (whitish exudate and longitudinal striae), with the increase of oeosinophils, showing persistence of the condition. Due to this, subsequent treatment with topical corticosteroids and an empiric exclusion diet was started. Author comment: Prolonged treatment with corticosteroids may also have altered the oral microbiota and contribute to the proliferation of actinomyces. Given that this is the first description of this association between eosinophilic oesophagitis and oesophageal actinomycosis, the appearance of new cases should be monitored to accurately delimit what the risk factors are, whether inherent to the disease or to its treatment with corticosteroids, which may predispose to local Actinomyces infection. Rodriguez-Lago I, et al. First case report of oesophageal actinomycosis in a patient with active eosinophilic oesophagitis. Gastroenterologia y Hepatologia 40: 404-406, No. 6, Jun-Jul 2017. Available from: URL: http://doi.org/10.1016/ j.gastrohep.2016.04.012 [Spanish; summarised from a translation] - Spain 803323544 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Budesonide

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46716-9
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p73 - 2 Jun 2018 Oesophageal actinomycosis: case report A 30-year-old man developed of oesophageal actinomycosis following prolonged treatment with budesonide [time to reaction onset not clearly stated]. The man, who had a history of hyperuricaemia and allergic asthma, presented with dysphagia for solids. He had received budesonide inhalations 200 400 µg/day continuously for a period of up to 2 years in a row. The budesonide treatment had been stopped from more than 3 years, and he was currently using terbutaline only. Gastroscopy revealed light rings in the distal third and fine longitudinal striations, indicating eosinophilic oesophagitis. He also showed a small sliding hiatal hernia. The biopsy findings reveled oesophageal epithelium with eosinophilic infiltrate, compatible with eosinophilic oesophagitis and colonies of actinomyces germs on the surface were observed. The man was treated with doxycycline for 4 weeks and showed clinical improvement in dysphagia; however, no complete resolution of symptoms occurred. Five months later, gastroscopy revealed signs of eosinophilic oesophagitis, whitish exudates and presence of the concentric rings. The biopsy confirmed eosinophilic oesophagitis, with no actinomyces colonies. Subsequently, he received treatment with omeprazole and fluticasone propionate [fluticasone] for eosinophilic oesophagitis. Despite a clinical improvement with treatment, he presented with self-limiting isolated episodes of dysphagia, for which a new endoscopic exploration was conducted one year later. Endoscopic signs of eosinophilic oesophagitis were observed (whitish exudate and longitudinal striae), with the increase of oeosinophils, showing persistence of the condition. Due to this, subsequent treatment with topical corticosteroids and an empiric exclusion diet was started. Author comment: Prolonged treatment with corticosteroids may also have altered the oral microbiota and contribute to the proliferation of actinomyces. Given that this is the first description of this association between eosinophilic oesophagitis and oesophageal actinomycosis, the appearance of new cases should be monitored to accurately delimit what the risk factors are, whether inherent to the disease or to its treatment with corticosteroids, which may predispose to local Actinomyces infection. Rodriguez-Lago I, et al. First case report of oesophageal actinomycosis in a patient with active eosinophilic oesophagitis. Gastroenterologia y Hepatologia 40: 404-406, No. 6, Jun-Jul 2017. Available from: URL: http://doi.org/10.1016/ j.gastrohep.2016.04.012 [Spanish; summarised from a translation] - Spain 803323544 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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