Langenbecks Arch Surg (2017) 402:863–871 DOI 10.1007/s00423-017-1609-2 REVIEW ARTICLE 1 2 1,3 Dagmar Kollmann & Nazia Selzner & Markus Selzner Received: 7 July 2017 /Accepted: 19 July 2017 /Published online: 28 July 2017 Springer-Verlag GmbH Germany 2017 Abstract radiotherapy, further possibilities for an individualized bridg- Background Liver transplantation (LT) is the only cure for ing therapy for patients with HCC have been developed. patients diagnosed with unresectable hepatocellular carcino- Patients with compensated liver cirrhosis and small tumour ma (HCC), and HCC has become the leading indication for LT size are preferably treated with RFA, whereas patients with in the USA. The shortage of liver grafts results in a significant larger tumour size but compensated liver function are treated waiting time for LT with the risk of tumour progression. with TACE/TARE. Patients with uncompensated liver cirrho- Treating HCCs during the waiting time prior to transplantation sis and larger tumour size can nowadays be successfully (bridging therapy) is an attractive strategy to reduce the risk of bridged to LT with external radiotherapy without increasing exceeding the tumour criteria for transplantation. Studies on the risk for further deterioration of liver function. bridging therapy are heterogenous and due to ethical issues, . .
Langenbeck's Archives of Surgery – Springer Journals
Published: Jul 28, 2017
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