Boric acid-catalyzed multi-component reaction for efficient synthesis of 4H-isoxazol-5-ones in aqueous medium

Boric acid-catalyzed multi-component reaction for efficient synthesis of 4H-isoxazol-5-ones in... The one-pot three-component reaction of aryl aldehydes with hydroxylamine hydrochloride and ethyl 3-oxobutanoate/ethyl 4-chloro-3-oxobutanoate/ethyl 3-oxo-3-phenylpropanoate in the presence of boric acid, H3BO3, in water leads to 4H-isoxazol-5(4H)-ones in high yields. The merits of this method are efficiency, simplicity, clean, green, easy work-up, high yields, and shorter reaction times. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Boric acid-catalyzed multi-component reaction for efficient synthesis of 4H-isoxazol-5-ones in aqueous medium

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1411-x
Publisher site
See Article on Publisher Site

Abstract

The one-pot three-component reaction of aryl aldehydes with hydroxylamine hydrochloride and ethyl 3-oxobutanoate/ethyl 4-chloro-3-oxobutanoate/ethyl 3-oxo-3-phenylpropanoate in the presence of boric acid, H3BO3, in water leads to 4H-isoxazol-5(4H)-ones in high yields. The merits of this method are efficiency, simplicity, clean, green, easy work-up, high yields, and shorter reaction times.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 8, 2013

References

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