Arch Virol (2005) 150: 1267 DOI 10.1007/s00705-005-0553-6 Mahy, B. W. J. (ed.): Foot-and-Mouth Disease Virus. Current Topics in Micro- biology and Immunology vol 288, 178 pp. Springer, Berlin Heidelberg New York Tokyo 2004. ISBN 3-540-22419. Following on the 2001 outbreak of foot-and-mouth (FMD) disease in England, after a disease- free period of 33 years, this is a timely volume that summarizes our current knowledge of FMD pathogenesis and epidemiology as well as of the FMD virus. The book comprises seven chapters: 1. The history of FMD virus (B. W. J. Mahy); 2. FMD: host range and pathogenesis (S. Alexandersen and G. N. Mowat); 3. Translation and replication of FMD virus RNA (G. J. Belsham); 4. The structure of FMD virus (E. E. Fry, D. I. Stuart and D. J. Rowlands); 5. Natural and vaccine induced immunity (T. R. Doel); 6. Global epidemiology and prospects for control (R. P. Kitching); 7. FMD virus evolution: exploring pathways towards virus extinction (E. Domingo et al.). The authors are all recognized experts on various aspects of the disease and its aetiological viral agent and they provide the latest scientiﬁc information needed to reassess the current controversial policy of not vaccinating against FMD and relying instead on slaughtering infected animals in order to control the disease. The decision to stop vaccination in Europe at the end of 1991 was based mainly on the policy that vaccinated animals were not accepted by countries free of the disease, which meant that their trading value was lost. Earlier FMD vaccines contained non-structural proteins in addition to the capsid proteins and vaccinated animals could therefore elicit the type of antibodies to non-structural proteins that are normally indicative of infected animals. Since modern FMD vaccines are free of nonstructural proteins, they will not elicit such antibodies and it is thus now possible, using adequate immunoassays, to discriminate between vaccinated animals and animals previously infected by the virus . An effective vaccination programme needs to take account of the fact that maternally derived antibodies may inhibit the ability of young calves to respond to FMD vaccines but this presents no insuperable problem. The slaughtering of large numbers of animals carried out during the 2001 outbreak seems to have led to a reappraisal of the no vaccination policy. The increased knowledge of FMD presented in this volume may help to develop control measures that are more effective than those implemented during the last 15 years. M. H. V. van Regenmortel Strasbourg
Archives of Virology – Springer Journals
Published: Jun 1, 2005
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