Bone Marrow Niche: Role of Different Cells in Bone Metastasis

Bone Marrow Niche: Role of Different Cells in Bone Metastasis Purpose of Review This report summarizes current knowledge of bone marrow hematopoietic stem cell (HSC) niche, focusing on the identification of niche cells and molecular mechanisms involved in HSC maintenance and bone metastasis. Recent Findings Novel imaging techniques are greatly improving our understanding of bone marrow niche and latest studies have revealed several complex multicellular regulatory mechanisms of niche function. Especially, the intriguing role of bone marrow macrophages and osteomacs is an emerging topic in the field. It appears that, e.g., macrophage polarization is important for communication with bone marrow stromal cells (BMSCs). Bone marrow is also a favorable environment for disseminated tumor cells and recent data shows that various niche cell types, including endothelial cells and BMSCs, regulate the progression of bone metastasis. Summary Bone marrow niche represents a multicellular system with complex interactions. Emerging data is providing us with a deeper understanding of this fascinating tissue and its role in metastasis. . . . . . Keywords Bone marrow niche Hematopoietic stem cells Bone marrow stromal cells Myeloid cells Bone metastasis Disseminated tumor cells Introduction pothesis in vivo. Studies indicated that osteogenic lineage cells could regulate stem cells in vivo but it remained unclear A niche is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Molecular Biology Reports Springer Journals

Bone Marrow Niche: Role of Different Cells in Bone Metastasis

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Molecular Medicine; Human Genetics
eISSN
2198-6428
D.O.I.
10.1007/s40610-018-0091-0
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review This report summarizes current knowledge of bone marrow hematopoietic stem cell (HSC) niche, focusing on the identification of niche cells and molecular mechanisms involved in HSC maintenance and bone metastasis. Recent Findings Novel imaging techniques are greatly improving our understanding of bone marrow niche and latest studies have revealed several complex multicellular regulatory mechanisms of niche function. Especially, the intriguing role of bone marrow macrophages and osteomacs is an emerging topic in the field. It appears that, e.g., macrophage polarization is important for communication with bone marrow stromal cells (BMSCs). Bone marrow is also a favorable environment for disseminated tumor cells and recent data shows that various niche cell types, including endothelial cells and BMSCs, regulate the progression of bone metastasis. Summary Bone marrow niche represents a multicellular system with complex interactions. Emerging data is providing us with a deeper understanding of this fascinating tissue and its role in metastasis. . . . . . Keywords Bone marrow niche Hematopoietic stem cells Bone marrow stromal cells Myeloid cells Bone metastasis Disseminated tumor cells Introduction pothesis in vivo. Studies indicated that osteogenic lineage cells could regulate stem cells in vivo but it remained unclear A niche is

Journal

Current Molecular Biology ReportsSpringer Journals

Published: Mar 24, 2018

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