Graefes Arch Clin Exp Ophthalmol (2017) 255:1581–1592 DOI 10.1007/s00417-017-3690-1 BASIC SCIENCE Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats 1 2 2 1 Biji Mathew & Jacqueline N. Poston & John C. Dreixler & Leianne Torres & 1 3 4 4 Jasmine Lopez & Ruth Zelkha & Irina Balyasnikova & Maciej S. Lesniak & 1,3 Steven Roth Received: 18 January 2017 /Revised: 19 April 2017 /Accepted: 26 April 2017 /Published online: 18 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract STR, and P2, and attenuated apoptosis as evidenced by de- Purpose Ischemia-associated retinal degeneration is one of creased TUNEL and caspase-3 protein levels. BMSCs signif- the leading causes of vision loss, and to date, there are no icantly increased autophagy, decreased inflammatory media- effective treatment options. We hypothesized that delayed in- tors (TNF-α, IL-1β, IL-6), and diminished retinal vascular jection of bone-marrow stem cells (BMSCs) 24 h after the permeability. BMSCs persisted in the vitreous and were also onset of ischemia could effectively rescue ischemic retina found within ischemic retina. from its consequences, including apoptosis, inflammation, Conclusions Taken together, our results indicate that intravit- and increased vascular permeability, thereby preventing reti- real injection of BMSCs rescued
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: May 18, 2017
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