Bone Marrow Adipose Tissue and Skeletal Health

Bone Marrow Adipose Tissue and Skeletal Health Purpose of Review To summarize and discuss recent progress and novel signaling mechanisms relevant to bone marrow adipocyte formation and its physiological/pathophysiological implications for bone remodeling. Recent Findings Skeletal remodeling is a coordinated process entailing removal of old bone and formation of new bone. Several bone loss disorders such as osteoporosis are commonly associated with increased bone marrow adipose tissue. Experimental and clinical evidence supports that a reduction in osteoblastogenesis from mesenchymal stem cells at the expense of adipogenesis, as well as the deleterious effects of adipocyte-derived signaling, contributes to the etiology of osteoporosis as well as bone loss associated with aging, diabetes mellitus, post-menopause, and chronic drug therapy. However, this view is challenged by findings indicating that, in some contexts, bone marrow adipose tissue may have a beneficial impact on skeletal health. Summary Further research is needed to better define the role of marrow adipocytes in bone physiology/pathophysiology and to determine the therapeutic potential of manipulating mesenchymal stem cell differentiation. . . . . Keywords Adipocyte Bone Differentiation Mesenchymal stem cell Osteoblast Introduction of bone marrow adipocytes on the critical physiological process of bone remodeling as well as the relevance of these cells to Bone marrow is a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Osteoporosis Reports Springer Journals

Bone Marrow Adipose Tissue and Skeletal Health

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Orthopedics; Epidemiology
ISSN
1544-1873
eISSN
1544-2241
D.O.I.
10.1007/s11914-018-0451-y
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review To summarize and discuss recent progress and novel signaling mechanisms relevant to bone marrow adipocyte formation and its physiological/pathophysiological implications for bone remodeling. Recent Findings Skeletal remodeling is a coordinated process entailing removal of old bone and formation of new bone. Several bone loss disorders such as osteoporosis are commonly associated with increased bone marrow adipose tissue. Experimental and clinical evidence supports that a reduction in osteoblastogenesis from mesenchymal stem cells at the expense of adipogenesis, as well as the deleterious effects of adipocyte-derived signaling, contributes to the etiology of osteoporosis as well as bone loss associated with aging, diabetes mellitus, post-menopause, and chronic drug therapy. However, this view is challenged by findings indicating that, in some contexts, bone marrow adipose tissue may have a beneficial impact on skeletal health. Summary Further research is needed to better define the role of marrow adipocytes in bone physiology/pathophysiology and to determine the therapeutic potential of manipulating mesenchymal stem cell differentiation. . . . . Keywords Adipocyte Bone Differentiation Mesenchymal stem cell Osteoblast Introduction of bone marrow adipocytes on the critical physiological process of bone remodeling as well as the relevance of these cells to Bone marrow is a

Journal

Current Osteoporosis ReportsSpringer Journals

Published: May 31, 2018

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