Osteoporos Int (2017) 28:2591–2600 DOI 10.1007/s00198-017-4098-9 ORIGINAL ARTICLE Bone loss with antiepileptic drug therapy: a twin and sibling study 1,2 1 1,3 1 4 B. Shiek Ahmad & S. J. Petty & A. Gorelik & T. J. O’Brien & K. D. Hill & 1 5 1,6 J. J. Christie & P. N. Sambrook & J. D. Wark Received: 12 January 2017 /Accepted: 16 May 2017 /Published online: 6 June 2017 International Osteoporosis Foundation and National Osteoporosis Foundation 2017 Abstract measured twice, at least 2 years apart. The mean within-pair Summary Changes in areal bone mineral density (aBMD) and difference (MWPD), MWPD%, and mean annual rate of other predictors of bone loss were evaluated in 48 same-sex aBMD change were adjusted for age, weight, and height. twin/age-matched sibling pairs discordant for antiepileptic Predictors of bone loss were evaluated. drug (AED) use. AED users had reduced BMD at the hip Results AED users, compared to non-users, at baseline and regions. Prolonged AED users had greater aBMD loss, follow-up, respectively, had reduced aBMD at the total hip predicting a higher risk of bone fragility. (MWPD% 3.8, 4.4%), femoral neck (4.7, 4.5%), and trochan- Introduction To investigate the longitudinal associations of ter regions
Osteoporosis International – Springer Journals
Published: Jun 6, 2017
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